Table III.
Prognostic index for HCC patients based on alternative splicing events.
| Symbol | AS ID | Splice type | Coefficient | z score | P-value |
|---|---|---|---|---|---|
| ZFAND6 | 32171 | AA | −8.51E-01 | −2.83 | 0.0047 |
| SWI5 | 87732 | AA | 8.52E-01 | 2.46 | 0.01392 |
| BIRC2 | 18447 | AA | −1.28E+01 | −4.66 | 3.20E-06 |
| RPS14 | 74096 | AD | −2.55E+00 | −4.38 | 1.20E-05 |
| PGRMC2 | 70577 | AD | −3.42E+01 | −4.58 | 4.70E-06 |
| CCDC90B | 18085 | AD | 8.30E-01 | 2.57 | 0.0102 |
| APOC1 | 50361 | AD | 4.11E+00 | 3.32 | 0.00089 |
| RTN4 | 53584 | AP | −4.26E-01 | −3.29 | 0.001 |
| RPL23A | 39967 | AP | −9.34E+01 | −2.57 | 0.01003 |
| RPL23A | 39965 | AP | −3.06E+00 | −3.44 | 0.00059 |
| RCL1 | 85779 | AP | 4.21E-01 | 2.92 | 0.00347 |
| NUDT6 | 70523 | AP | 2.19E-01 | 2.16 | 0.03054 |
| NUDT6 | 70521 | AP | 6.16E-01 | 3.07 | 0.00216 |
| MXI1 | 13080 | AP | 1.53E-01 | 1.49 | 0.13594 |
| MXI1 | 13079 | AP | 4.76E-01 | 2.67 | 0.00752 |
| IAH1 | 52628 | AP | 1.41E+01 | 4.98 | 6.30E-07 |
| DUSP22 | 75126 | AP | −2.38E-01 | −1.76 | 0.07903 |
| DUSP22 | 75125 | AP | 9.50E-01 | 3.53 | 0.00041 |
| CYB5A | 45803 | AP | 1.29E+00 | 3.29 | 0.00099 |
| CHPF | 57718 | AP | −1.64E+00 | −2.21 | 0.02698 |
| CARKD | 26251 | AP | −2.49E-01 | −1.71 | 0.08786 |
| IAH1 | 52629 | AP | 4.82E-01 | 3 | 0.00273 |
| ZSCAN20 | 1679 | AT | −7.88E-01 | −3.12 | 0.00182 |
| ZNF706 | 84738 | AT | −1.42E+01 | −5.76 | 8.40E-09 |
| WWOX | 37672 | AT | −5.47E+00 | −7.13 | 9.70E-13 |
| TROAP | 21551 | AT | 3.63E-01 | 1.56 | 0.11927 |
| RAPH1 | 57075 | AT | 1.48E+00 | 1.83 | 0.0673 |
| RAPH1 | 57074 | AT | 5.54E-01 | 2.8 | 0.00504 |
| NUCB2 | 14523 | AT | −9.05E+00 | −2.22 | 0.0262 |
| FRMD4A | 10810 | AT | 5.09E+00 | 5.4 | 6.50E-08 |
| CRISPLD2 | 37867 | AT | 8.61E-01 | 3.72 | 0.0002 |
| CLSPN | 1731 | AT | −8.03E-01 | −1.74 | 0.08206 |
| BCAM | 50347 | AT | −3.64E-01 | −1.6 | 0.11049 |
| ACAT1 | 18599 | AT | 2.88E+00 | 4.6 | 4.30E-06 |
| XPC | 63523 | ES | 2.96E-01 | 1.79 | 0.0731 |
| WIPI2 | 78656 | ES | −3.47E-01 | −1.98 | 0.04758 |
| TRAPPC6A | 50409 | ES | −3.27E+00 | −4.69 | 2.70E-06 |
| TPRA1 | 66613 | ES | −4.71E+00 | −1.84 | 0.06575 |
| TMEM150A | 54305 | ES | 1.66E+00 | 2.85 | 0.00443 |
| TMEM141 | 88206 | ES | −3.62E-01 | −3.7 | 0.00022 |
| TCF3 | 46542 | ES | −1.57E+00 | −4.66 | 3.10E-06 |
| STRA13 | 44266 | ES | 2.97E+00 | 4.89 | 1.00E-06 |
| SSR4 | 90499 | ES | 2.39E+02 | 6.3 | 3.00E-10 |
| SLC7A9 | 48907 | ES | 3.61E-01 | 3.17 | 0.0015 |
| SLC25A45 | 16828 | ES | 3.71E-01 | 2.05 | 0.04004 |
| SLAIN2 | 69214 | ES | −6.78E-01 | −2.89 | 0.00385 |
| SHBG | 39015 | ES | −8.49E-01 | −7.07 | 1.50E-12 |
| PTRH1 | 87649 | ES | −6.58E+01 | −5.47 | 4.40E-08 |
| PPP2CB | 83304 | ES | −5.52E+02 | −5.72 | 1.10E-08 |
| PGAP3 | 40670 | ES | 2.10E+01 | 3.32 | 0.00089 |
| OCEL1 | 48244 | ES | −5.74E+00 | −2.97 | 0.00298 |
| MTA1 | 29647 | ES | −3.93E-01 | −2.25 | 0.02464 |
| MPPE1 | 44648 | ES | −3.09E-01 | −2.34 | 0.01921 |
| MPND | 46796 | ES | −6.87E+00 | −2.12 | 0.034 |
| LTBP3 | 16865 | ES | −4.93E-01 | −1.87 | 0.06167 |
| JOSD2 | 51205 | ES | −5.21E+00 | −2.51 | 0.0119 |
| ISOC2 | 52106 | ES | −5.98E+00 | −3.29 | 0.00099 |
| IRF3 | 50991 | ES | −7.04E+01 | −2.94 | 0.00327 |
| IRF3 | 50990 | ES | 5.08E-01 | 2.41 | 0.01599 |
| GUK1 | 10185 | ES | −2.01E+01 | −3.77 | 0.00016 |
| ECHDC2 | 3037 | ES | 6.27E-01 | 3.96 | 7.50E-05 |
| DGKZ | 15546 | ES | −8.54E-01 | −2.5 | 0.01235 |
| CSAD | 21952 | ES | 8.72E-01 | 3.91 | 9.30E-05 |
| CLASRP | 50393 | ES | −1.15E+00 | −2.99 | 0.00281 |
| CHRD | 67959 | ES | −5.44E-01 | −3.86 | 0.00011 |
| C17orf49 | 38825 | ES | 2.01E+01 | 3.52 | 0.00043 |
| C16orf13 | 32921 | ES | 2.25E+00 | 2.39 | 0.01699 |
| C16orf13 | 32919 | ES | −3.45E+00 | −3.98 | 6.80E-05 |
| BAX | 50838 | ES | −4.99E+01 | −3.86 | 0.00011 |
| ARHGEF10L | 862 | ES | 4.31E-01 | 1.83 | 0.06684 |
| APOC1 | 99361 | ES | −2.72E-01 | −3.56 | 0.00037 |
| AFMID | 94694 | ES | 2.79E-01 | 1.98 | 0.04811 |
| AFMID | 94690 | ES | 4.05E-01 | 2.62 | 0.00888 |
| AFMID | 43800 | ES | −1.21E+00 | −4.21 | 2.50E-05 |
| AFMID | 43798 | ES | 7.48E-01 | 3.04 | 0.00236 |
| AFMID | 43795 | ES | −5.04E-01 | −4.01 | 6.00E-05 |
| ACY1 | 65150 | ES | 3.56E+01 | 1.76 | 0.07779 |
| SLC39A14 | 140283 | ME | 3.82E-01 | 2.9 | 0.00372 |
| H2AFY | 96931 | ME | 2.26E+00 | 3.09 | 0.00198 |
| CYP4F3 | 48101 | ME | −3.19E-01 | −2.94 | 0.00327 |
| VPS28 | 85600 | RI | −7.11E-01 | −2.25 | 0.02443 |
| ROMO1 | 59223 | RI | 7.85E-01 | 2.64 | 0.00822 |
| NUDT22 | 16590 | RI | 2.71E+00 | 5.83 | 5.70E-09 |
| MRPL52 | 26642 | RI | 1.11E+00 | 4.03 | 5.60E-05 |
AS, alternative splicing; HCC, hepatocellular carcinoma; AA, alternate acceptor sites; AD, alternate donor sites; AP, alternate promoters; AT, alternate terminators; ES, exon skipping; ME, mutually exclusive exons; RI, retained introns.