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. 2019 Jun 6;55(2):473–487. doi: 10.3892/ijo.2019.4823

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Copyright: © Wang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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CSE knockdown inhibits human breast cancer metastasis in nude mice. Hematoxylin and eosin staining of lung tissues of nude mice was performed in order to analyze the effect of the expression of CSE on breast cancer metastasis in vivo. The results revealed that the rate of lung metastases was 75% in nude mice receiving MDA-MB-231 cells with CSE expression. CSE knockdown MDA-MB-231 cells resulted in a decrease of the rate of lung metastases (12.5%) in nude mice and only led to intravascular tumor thrombus. CSE, cystathionine-γ-lyase.