. 2019 Mar 14;37(8):1574–1586. doi: 10.1097/HJH.0000000000002088

TABLE 4.

Results of recent meta-analyses in hypertensive patients

Study	Versus		BP adj	Cardiovascular events	Coronary heart disease	Cerebrovascular events/stroke	Heart failure	Cardiovascular mortality	All-cause mortality
Olde Engberink et al., 2015 [81]
Thiazide-like^b	PL	RR [95% CI]	No	0.67 [0.60–0.75]^a	–	0.68 [0.57–0.80]^a	0.47 [0.36–0.61]^a	–	0.84 [0.74–0.96]^a
Thiazide^b	PL	RR [95% CI]	No	0.67 [0.56–0.81]^a	–	0.52 [0.38–0.69]^a	0.36 [0.16–0.84]^a	–	0.86 [0.75–1.00]
Thiazide-like^b	PL	RR [95% CI]	Yes	0.88 [0.79–0.98]^a	–	–	0.71 [0.57–0.89]^a	–	–
Thiazide^b	PL	RR [95% CI]	Yes	1.00 [0.91–1.09]	–	–	0.90 [0.68–1.21]	–	–
Chen et al., 2015 [82]^c
Thiazide-like^d	Ac + PL	OR [95% CI]	No	0.78 [0.68–0.90]^a	0.98 [0.91–1.05]	0.82 [0.70–0.96]^a	0.57 [0.41–0.76]^a	–	–
Thiazide^d	Ac + PL	OR [95% CI]	No	0.92 [0.79–1.07]	0.96 [0.78–1.19]	1.03 [0.67–1.56]	0.71 [0.44–1.15]	–	–
Thomopoulos et al., 2015 [83]
Chlorthalidone	Ac + PL	RR [95% CI]	Yes	–	0.69 [0.49–0.97]^a	0.63 [0.50–0.80]^a	0.48 [0.35–0.67]^a	0.80 [0.61–1.04]	0.89 [0.75–1.06]
Indapamide	Ac + PL	RR [95% CI]	Yes	–	1.02 [0.63–1.65]	0.73 [0.61–0.87]^a	–	0.83 [0.69–1.01]	0.86 [0.75–0.99]^a
Thiazide^e	Ac + PL	RR [95% CI]	Yes	–	0.80 [0.56–1.15]	0.59 [0.41–0.85]^a	0.81 [0.45–1.46]	0.79 [0.65–0.95]^a	0.92 [0.81–1.05]
United Kingdom National Clinical Guideline Centre [2]
Bendroflumethiazide	PL	HR [95% CI]	–	0.78 [0.65–0.94]^a	1.00 [0.80–1.25]	0.44 [0.30–0.63]^a	–	–	1.00 [0.81–1.24]
Chlorthalidone	PL	HR [95% CI]	–	4.31 [0.27–68.84]	2.0 [0.86–4.67]	0.63 [0.49–0.80]^a	–	–	0.87 [0.73–1.04]
Indapamide	PL	HR [95% CI]	–	0.77 [0.64–0.93]^a	0.53 [0.36–0.77]^a	0.72 [0.61–0.87]^a	–	–	0.85 [0.74–0.99]^a

^aSignificant versus comparator.

^bThiazide-like constitutes chlorthalidone and indapamide; thiazide constitutes chlorothiazide, hydrochlorothiazide, trichlormethiazide, bendroflumethiazide, bendrofluazide.

^cNo adjustment for blood pressure.

^dThiazide-like, indapamide, chlorthalidone, metolazone; thiazide, chlorothiazide; HCTZ, methyclothiazide, trichlormethiazide, polythiazide, bendroflumethiazide.

^eHydrochlorothiazide and bendroflumethiazide. Ac, active; BP adj, blood pressure adjustment; CI, confidence interval; HR, hazard ratio; OR, odds ratio; PL, placebo; RR, risk reduction. Significant values are indicated in bold.