. Author manuscript; available in PMC: 2020 Jul 1.

Published in final edited form as: Biol Blood Marrow Transplant. 2019 Feb 14;25(7):e226–e246. doi: 10.1016/j.bbmt.2019.02.012

Table 8.

Cost of ERT for different types of MPS [2, 110]

Type of MPS	Recombinant enzyme deficient	Drug name	Dosage (mg/kg of body weight) once a week	Wholesale acquisition cost per year for 25 kg patient
MPS I	Larondiase	Aldurazyme	0.58 mg/kg	$218,000
MPS II	Idursulfase	Elaprase	0.5 mg/kg	$340,000
MPS IVA	Elosulfase alfa	Vimizim	2 mg/kg	$578,000
MPS VI	Galsulfase	Naglazyme	1 mg/kg	$476,000
MPS VII	Vestronidase alfa	Mepsevii	4 mg/kg bi-weekly	$550,000

Note; Compared with other countries, the overall annual cost for ERT differs slightly depending on the country, for example, the cost of ERT annually in Japan for a 25 kg MPS II patient is $400,000 [13].