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. Author manuscript; available in PMC: 2020 Aug 1.
Published in final edited form as: Mol Neurobiol. 2019 Jan 16;56(8):5568–5585. doi: 10.1007/s12035-019-1467-8

Figure 10. Activation of mGluR1 signaling by specific mGluR agonist dihydroxyphenylglycine (DHPG) upregulated hippocampal C1q expression.

Figure 10.

Microinjection of DHPG into the hippocampal CA1 in naïve rats induced dephosphorylation of FMRP (a, n = 6 rats in each group, Mann-Whitney U-statistic = 35.00, two-tailed P = 0.007), decreased the binding between phosphorylated FMRP (p-FMRP) and C1q mRNA (b, n = 6 rats in each group, Mann-Whitney U-statistic = 33.00, two-tailed P = 0.015), and increased C1q mRNA in the hippocampal CA1 synaptosome (c, n = 6 rats in each group, t = 2.8, DF = 10, two-tailed P = 0.018). DHPG also increased the C1q immunosignal co-localized with PSD95 in the hippocampal CA1 in the naïve rats (d, n = 5 rats in each group, t = 12.6, DF = 8, two-tailed P <0.0001, scale bar = 10 μm). Each dot represents the mean value of 4 brain sections of one rat. Data represent mean ± s.e.m. *P<0.05, **P<0.01, ***P<0.001.