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. Author manuscript; available in PMC: 2020 Aug 1.
Published in final edited form as: Mol Neurobiol. 2019 Jan 16;56(8):5568–5585. doi: 10.1007/s12035-019-1467-8

Figure 2. Increased microglial phagocytosis of glutamatergic synapses in rodent AD model.

Figure 2.

Increased internalization of postsynaptic marker PSD95 was observed in the lysosomes (CD68) within the microglia (Iba1) in the rats injected with Aβ1–40 fibrils, but not those injected with Aβ40–1 fibrils (a, n = 5 rats in each group, F2,12 = 67.6, P<0.0001, scale bar = 10 μm). A micrograph was presented at the right to show the same microglia in which only the lysosomes (red) and PSD95 (green) were visualized. Similar increases in co-localization of PSD95 with lysosome marker CD68 within the microglia were observed in the hippocampal CA1 of the Tg-APPsw/PSEN1DE9 (APP/PSI) mice (b, n = 5 mice in each group, Mann-Whitney U-statistic <0.0001, two-tailed P = 0.008, scale bar = 10 μm). Data represent mean ± s.e.m. Each dot represents the mean value of 4 brain sections of one animal. **P<0.01, ***P<0.001.