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. Author manuscript; available in PMC: 2020 Aug 1.
Published in final edited form as: Mol Neurobiol. 2019 Jan 16;56(8):5568–5585. doi: 10.1007/s12035-019-1467-8

Figure 4. Increased C1q distribution in the glutamatergic synapse.

Figure 4.

Significantly increased C1q expression was observed in the hippocampal synaptosomal preparation of the rats injected with amyloid fibrils, which was effectively attenuated by C1q siRNA (a, n = 7 rats in each group, F3,24 = 6.3, P = 0.0026). Significantly increased co-localization of C1q with PSD95 was observed in the hippocampal CA1 of the rats injected with Aβ1–40 fibrils, but not those injected with Aβ40–1 fibrils (b, n = 5 rats in each group, F4,20 = 42.8, P <0.0001, scale bar = 10 μm). Each dot represents the mean value of 4 brain sections of one animal. Significantly increased expression of C1q was observed in hippocampal CA1 synaptosomal preparation in the Tg-APPsw/PSEN1DE9 (APP/PSI) compared to C57BL/6 mice (c, n = 8 mice in each group, unpaired t-test, t = 3.7, DF = 14, two-tailed P = 0.002). Data represent mean ± s.e.m. *P<0.05, **P<0.01, ***P<0.001.