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. Author manuscript; available in PMC: 2020 Jul 15.
Published in final edited form as: J Immunol. 2019 Jun 5;203(2):370–378. doi: 10.4049/jimmunol.1900388

FIGURE 2.

FIGURE 2.

Helios deficient mice do not display major defects. (A) Splenocytes from 4-6 mo old Ikzf2fl/fl and Ikzf2fl/fl × CD4Cre mice were gated on CD4+ T cells and analyzed for the frequency of Treg, TM, and TFH cells, as well as the number of GC B cells (B220+IgDloFas+GL7+). (B) Ikzf2fl/fl and Ikzf2fl/fl × CD4Cre mice were immunized i.p. with SRBC. Spleens were harvested 8d post immunization and analyzed for the expression of TFH markers among CD4+ Foxp3− T cells (C) and the number of GC B cells.