Table 3.
Structure-based alignmenta
| Chain | Chain | RMSDb | RMSD without Activation Segmentc |
|---|---|---|---|
| A | B | 1.37 | 1.06 |
| A | C | 5.15 | 0.94 |
| B | C | 5.19 | 1.07 |
| A | Phospho-PKR kinased | 5.24 | 1.04 |
| B | Phospho-PKR kinased | 5.27 | 1.13 |
| C | Phospho-PKR kinased | 1.90 | 1.22 |
a
Structure-based alignment of the three subunits of the PKR-AMPPNP complex performed using PYMOL (The PyMOL Molecular Graphics System, Version 2.2.0), Schrödinger, LLC).
b
Root-mean square deviation of the aligned atoms (Å).
c
Root-mean square deviation of the aligned atoms omitting the activation segment residues 439–466 (Å).
d
PKR kinase domain phosphorylated on residue T446 corresponding to chain B of the PKR kinase – eIF2α crystal structure PDB ID 2A19. 17