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. Author manuscript; available in PMC: 2020 Jul 15.
Published in final edited form as: Acta Biomater. 2019 Jan 31;93:222–238. doi: 10.1016/j.actbio.2019.01.061

Figure 3.

Figure 3.

Intra-articular Drug Delivery Systems. [A] Materials used for nano- and micro-spheres, liposomes, and microcapsules span a wide range of sizes (10nm – 1mm). [B] Hydrogel “drug depots” can extend drug release within the joint. [C] Targeting molecules (e.g. WYRGRL) can focus delivery to the damaged cartilage interface. [D] Cationic particles can increase penetrance for improved drug delivery within cartilage tissue. [E] Drug delivery vehicles can target specific cells and structures (e.g. chondrocytes, synovial fibroblasts, angiogenic regions).