Table 2:
Characteristics of Study Sample at the Time of MRI Scan1
| Seronegative | Seropositive | Effect Size2 | ||||||
|---|---|---|---|---|---|---|---|---|
| Trajectory | Normal | Premature Aging | Abnormal | Normal | Premature Aging | Abnormal | Serostatus | Trajectory |
| Number | 103 | 22 | 5 | 124 | 35 | 9 | ||
| Age3 (mean, S.D., Range) | 59.3 (7.1) (50.3–78.5) |
58.9 (5.8) (51.1–76.1) |
53.6 (3.0) (51.6–64.5) |
56.2 (4.5) (48.3–76.5) |
56.0 (5.2) (50.2–76.4) |
56.9 (5.8) (52.4–67.0) |
.002 | .007 |
| Education | 16.8 (2.5) | 16.9 (2.4) | 16.7 (2.3) | 15.7 (2.3) | 16.5 (4.0) | 15.6 (1.7) | .007 | .006 |
| Cohort (%(n) Cohort 3) | 13.6 | 27.3 | 0.0 | 29.0 | 48.6 | 7.0 | .16* | .21* |
| Race (%(n) Caucasian) | 87.4 | 81.8 | 100 | 75.0 | 54.3 | 66.7 | .15* | .20* |
| Diabetes | 9.7 | 31.8 | 0.0 | 14.5 | 20.0 | 0.0 | .16* | .03 |
| Hypertension | 45.6 | 50.0 | 60.0 | 41.9 | 42.9 | 55.6 | .06 | .04 |
| Depressed | 14.7 | 15.0 | 0.0 | 24.1 | 24.2 | 0.0 | .10 | .11 |
| Cocaine | 9.7 | 13.6 | 20.0 | 25.8 | 37.1 | 44.4 | .12 | .22* |
| Amphetamines | 4.9 | 0.0 | 0.0 | 14.5 | 14.3 | 0.0 | .07 | .17* |
| AIDS | n/a | n/a | n/a | 12.9 | 20.0 | 11.1 | .10 | .11 |
| Detectable Virus | n/a | n/a | n/a | 16.4 | 30.4 | 37.5 | n/a | .09 |
| Current CD4+ | n/a | n/a | n/a | 691.1 (297) | 764.1 (477) | 973.1 (420) | n/a | .03* |
| Nadir CD4+ | n/a | n/a | n/a | 277.5 (156) | 264.1 (188) | 294.2 (255) | n/a | .002 |
| Current Viral Load | n/a | n/a | n/a | 1.60 (.84) | 1.83 (1.1) | 2.11 (1.3) | n/a | .03 |
| Peak Viral Load | n/a | n/a | n/a | 4.78 (.601) | 4.80 (.73) | 5.13 (.56) | n/a | .02 |
| CO WAT3 | 55.1 (1.4) | 45.7 (3.5) | 50.3 (6.7) | 53.4 (1.2) | 45.0 (2.3) | 46.9 (4.4) | .002 | .073* |
| Rey Osterreith Figure-Copy | 33.5 (.88) | 30.8 (2.3) | 29.0 (4.3) | 29.8 (.78) | 26.9 (1.5) | 30.4 (2.8) | .005 | .019 |
| Immediate Recall | 25.5 (.94) | 15.1 (2.4) | 17.0 (4.6) | 21.6 (.83) | 14.4 (1.6) | 17.1 (3.0) | .002 | .144* |
| Delayed Recall | 25.2 (.94) | 14.3 (2.4) | 18.2 (4.6) | 21.3 (.83) | 14.6 (1.6) | 16.1 (3.0) | .004 | .144* |
| Stroop Test-Interference | 95.8 (4.7) | 123.5 (12) | 147.3 (23) | 94.0 (4.1) | 119.2 (7.8) | 110.7 (15) | .009 | .072* |
| Grooved Pegboard-Dominant3 | 55.0 (1.8) | 42.0 (4.7) | 52.7 (9.0) | 51.4 (1.6) | 39.3 (3.1) | 45.1 (5.9) | .006 | .076* |
| Non-Dominant3 | 54.3 (1.8) | 43.7 (4.6) | 49.3 (8.8) | 49.8 (1.6) | 40.3 (3.0) | 49. (5.8) | .002 | .052* |
| Trailmaking A3 | 64.8 (2.2) | 53.9 (5.6) | 59.3 (11) | 58.3 (1.9) | 55.8 (3.6) | 58.0 (7.0) | .001 | .017* |
| Trailmaking B3 | 70.8 (2.2) | 55.3 (5.6) | 58.3 (11) | 59.6 (1.9) | 54.8 (3.6) | 54.0 (7.0) | .006 | .042* |
1)
Continuous (mean + s.d.) and discrete (percent) variables.
2)
(for continuous data) or Phi (for categorical data)
3)
Mean (± s.d.) and range
*
p<.05