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Different from ADAM10 and ADAM17, ADAM8 showed a positive correlation with the investigated MMPs, which was highly significant in both cases (MMP9/ADAM8: P = 0.0002865; MMP14/ADAM8: P = 0.0006515). ADAM8 seems to be clustering with MMP9 and MMP14 rather than ADAM10 and ADAM17 (ADAM10/ADAM8: P = 0.9526; ADAM17/ADAM8: P = 0.3532).
