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. 2019 Jun 20;39(6):BSR20190459. doi: 10.1042/BSR20190459

Figure 5. AMPK/mTOR/p70S6K signaling pathway was implicated in PHN-induced autophagy.

Figure 5

HEp-2 cells were treated with various concentrations of PHN (0, 1, 10 and 100 μM) for 24 h, and the expression of proteins associated with autophagy signal pathways was analyzed by Western blot. The expression levels of P-AMPK, AMPK, P-mTOR, mTOR, P-p70S6K, p70S6K, β-actin and quantitation of P-AMPK/AMPK, P-mTOR/mTOR and P-p70S6K/p70S6K ratios. The experiment was repeated three times independently and data are expressed as mean ± standard error, *P<0.05.