Table 3.
Peripheral and central hemodynamics by treatment group.
| Both delayed N = 14 | ISMN N = 15 | Cilostazol N = 13 | Both immediate N = 14 | Cilostazol vs. none (2 + 3 vs. 1 + 4*) | ISMN vs. none (1 + 3 vs. 2 + 4*) | Cil + ISMN vs. one or other (3 + 4 vs. 1 + 2) | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Peripheral hemodynamics, adjusted for baseline | Week 3 (4*) | Week 8 (4) | Week 8 (1) | Week 8 (2) | Week 8 (3) | MD (95% CI) | p-value | MD (95% CI) | p-value | MD (95% CI) | p-value |
| Systolic (mmHg), mean (SD) | 134.8 (12.4) | 131.4 (19.0) | 144.1 (16.5) | 146.7 (19.4) | 139.9 (20.7) | −1.11 (−8.38, 6.16) | 0.765 | −1.06 (−8.52, 6.40) | 0.780 | −4.91 (−11.71, 1.88) | 0.156 |
| Diastolic (mmHg), mean (SD) | 80.4 (9.7) | 78.0 (10.8) | 84.9 (7.6) | 81.3 (11.2) | 79.8 (10.5) | −1.63 (−5.84, 2.58) | 0.448 | −0.65 (−4.96, 3.66) | 0.768 | −2.56 (−6.50, 1.38) | 0.202 |
| Heart rate, mean (SD) | 74.3 (9.3) | 79.5 (11.2) | 74.7 (12.5) | 80.6 (15.0) | 84.8 (15.1) | 6.42 (1.17, 11.68) | 0.017 | 0.06 (−5.50, 5.62) | 0.984 | 3.13 (−1.93, 8.20) | 0.225 |
| Central hemodynamics, adjusted for baseline | |||||||||||
| Pulse wave velocity (m/s), mean (SD) | 8.4 (1.3) | 8.7 (1.4) | 8.7 (1.6) | 8.6 (1.3) | 8.2 (1.3) | −0.34 (−0.99, 0.30) | 0.296 | −0.14 (−0.84, 0.55) | 0.686 | 0.00 (−0.64, 0.64) | 0.996 |
| Augmentation index 75 (%), mean (SD) | 24.0 (10.6) | 16.2 (12.4) | 17.5 (12.9) | 23.0 (10.6) | 14.7 (10.5) | −4.79 (−9.72, 0.15) | 0.057 | −4.74 (−9.78, 0.30) | 0.066 | 0.09 (−4.76, 4.94) | 0.970 |
| Augmentation index (%), mean (SD) | 118.6 (28.3) | 123.3 (23.2) | 131.1 (16.8) | 121.1 (18.9) | 133.1 (25.0) | 3.46 (−8.65, 15.57) | 0.575 | 21.19 (9.08, 33.31) | 0.001 | 0.97 (−10.77, 12.71) | 0.871 |
| Central blood pressure (mmHg), mean (SD) | 99.0 (14.6) | 95.4 (12.7) | 101.2 (12.4) | 103.1 (11.8) | 98.8 (11.7) | −2.03 (−8.23, 4.17) | 0.521 | −4.74 (−10.67, 1.19) | 0.117 | −3.36 (−9.12, 2.40) | 0.253 |
| Buckberg index (%), mean (SD) | 154.4 (21.5) | 164.8 (22.2) | 166.6 (25.2) | 152.2 (31.4) | 132.9 (22.7) | −10.81 (−21.15, −0.47) | 0.040 | 6.75 (−3.59, 17.09) | 0.201 | −11.37 (−21.01, −1.72) | 0.021 |
CI, confidence intervals; ISMN, isosorbide mononitrate; MD, mean difference; SD, standard deviation. Augmentation index 75: normalized to heart rate 75 bpm.