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. 2019 Jul 3;9:593. doi: 10.3389/fonc.2019.00593

Table 2.

Univariate and multivariate analysis of overall survival after matching.

Characteristics Univariate Multivariate
HR 95%CI p-value HR 95%CI p-value
Age (years) 1.039 1.028–1.051 < 0.001* 1.039 1.028–1.051 < 0.001*
Sex < 0.001* 0.001*
    Male Reference Reference
    Female 0.671 0.554–0.813 < 0.001* 0.711 0.584–0.867 0.001*
Laterality 0.553
    Left Reference
    Right 0.944 0.780–1.142 0.553
Race 0.438
    White Reference
    Black 1.128 0.811–1.570 0.473
    Other 0.685 0.409–1.149 0.151
    Unknown 0.002 0–791532416 0.947
Marital status 0.028* 0.047*
    Married Reference Reference
    Unmarried 1.254 1.033–1.522 0.022 1.264 1.036–1.543 0.021*
    Unknown 0.725 0.385–1.366 0.320 0.830 0.439–1.568 0.565
Year at diagnosisa 0.179
Statea 0.173
Surgical lobe 0.697
    Upper Reference
    Middle 1.116 0.527–2.363 0.775
    Lower 0.894 0.729–1.096 0.280
    Unknown 1.239 0.307–4.994 0.763
Surgery 0.005* 0.009*
    Wedge Reference Reference
    Segmentectomy 0.759 0.626–0.920 0.005* 0.774 0.638–0.939 0.009*
Grade < 0.001* < 0.001*
    I Reference Reference
    II 2.041 1.533–2.716 < 0.001* 1.874 1.405–2.500 < 0.001*
    III 2.414 1.761–3.308 < 0.001* 2.448 1.776–3.375 < 0.001*
    IV 2.188 0.686–6.981 0.186 2.234 0.696–7.166 0.177
    Unknown 1.422 0.839–2.412 0.191 1.611 0.946–2.743 0.079
Stage < 0.001* 0.004*
    IA1 Reference
    IA2 1.738 1.247–2.423 0.001* 1.454 1.040–2.033 0.029*
    IA3 2.316 1.639–3.272 < 0.001* 1.757 1.237–2.496 0.002*

HR, hazard ratio; CI, confidence interval.

a

Detailed data of year at diagnosis and state are listed in Table S2.

*

Indicates p < 0.05.