FIGURE 3.
Bilateral attenuation of stem cell proliferation in the dentate gyri by intranigral injection of endotoxin. Quantification of BrdU positive cells in the ipsilateral and contralateral DG to the side of ET-intranigral injection, showing significant decreases in both sides. Each bar represents the average of counted BrdU-positive cells ± SEM of each dentate gyrus (contralateral or ipsilateral separately with reference to injected side). Measurements of significance between the ipsilateral and contralateral DG of ET is indicated by # and with their reference to sham by *. There was no significant difference between sham and naïve at all-time points, using student t-test; P < 0.01; ∗∗P < 0.01; ∗∗∗P < 0.001. Paired student t-test was used to determine significance between ipsilateral and contralateral counts within the same group.