FIGURE 3.
Bland-Altman plots of test-retest agreement between duplicate measurements of pathology from two distinct staining batches. Bland-Altman plots show test-retest agreement between SB1 and SB2 measurements of digital pathology (i.e., ln %AO). The green dashed line indicates the mean difference between SB1 and SB2 measurements, while the red solid lines mark the 95% limits of agreement between the two measurements. We find that mean difference between SB1 and SB2 significantly differs from zero (p < 0.001) in FTLD-Tau (A) and FTLD-TDP (B) in both GM and WM. FTLD-Tau, frontotemporal lobar degeneration with inclusions of the tau protein; FTLD-TDP, frontotemporal lobar degeneration with inclusions of the transactive response DNA-binding protein 43 kDa; GM, gray matter; SB1, staining batch 1 (original); SB2, staining batch 2 (new); WM, white matter.