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. 2019 Jul 3;10:613. doi: 10.3389/fgene.2019.00613

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Copyright © 2019 Ramos-Molina, Sánchez-Alcoholado, Cabrera-Mulero, Lopez-Dominguez, Carmona-Saez, Garcia-Fuentes, Moreno-Indias and Tinahones

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Association between the DNA methylation status of histone deacetylase 7 (HDAC7) and the gut microbiota composition in obese subjects. (A) Methylation of HDAC7 (쌠β value) in the HighBFR vs. LowBFR groups in both visceral adipose tissue and whole blood. Data (n = 10 per group) are plotted as means ± SE. Significance was tested using Mann–Whitney U test and is indicated as *p < 0.05. (B) Spearman correlations between HDAC7 methylation and the ratio Bact/Firm in both visceral adipose tissue and whole blood. (C) Spearman correlation between HDAC7 methylation and the relative abundance (%) of Firmicutes in whole blood. (D) Spearman correlation between HDAC7 methylation and the relative abundance (%) of Bacteroidetes in visceral adipose tissue.