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. 2019 Jul 3;9:554. doi: 10.3389/fonc.2019.00554

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Copyright © 2019 Belykh, Miller, Carotenuto, Patel, Cavallo, Martirosyan, Healey, Byvaltsev, Scheck, Lawton, Eschbacher, Nakaji and Preul.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Image brightness and background noise level with the generation 1 (Gen1) and generation 2 (Gen2) confocal laser endomicroscope (CLE). Image brightness and background noise level depend on the laser power and image brightness set up of the CLE. (A) Graph showing observed image intensity in arbitrary units (AU) (y axis) at the various brightness positions, while imaging normal brain area. This value represents “black” noise. Brightness setting above 80% results in a significant increase of black noise, which may decrease image quality. Therefore, when imaging, one should aim at getting a picture at a brightness level below 80%. (B) Unprocessed Gen 2 CLE images taken at various indicated brightness levels (%) that are set manually. Scale bars are 50 μm. Used with permission from Barrow Neurological Institute, Phoenix, Arizona.