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. 2019 Jul 3;9:554. doi: 10.3389/fonc.2019.00554

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Copyright © 2019 Belykh, Miller, Carotenuto, Patel, Cavallo, Martirosyan, Healey, Byvaltsev, Scheck, Lawton, Eschbacher, Nakaji and Preul.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Confocal laser endomicroscopy (CLE) images of normal mouse brain, GL261 brain glioma, visualized with and without fluorescein sodium (FNa), using (A) generation 1 (Gen1) and (B) generation 2 (Gen2) CLE. Brain vasculature, brain parenchyma, and tumor staining patterns were observed with similar quality between Gen1 and Gen2 systems. The insets show similarly magnified views from Gen1 and Gen2 systems. Additional hematoxylin and eosin (H&E) images are provided from the regions of interest of normal brain and glioma areas scanned with Gen1 and Gen2 CLE. Scale bars are 50 μm. Used with permission from Barrow Neurological Institute, Phoenix, Arizona.