Table 1.
Characteristics of the study population according to frailty assessed by FI-LAB
| N=1020 | Robust(n=701) | Pre-frail(n=269) | Frail(n=50) | P* |
|---|---|---|---|---|
| Age (years) | 64 (61,69) | 65 (63,69) | 67 (62,70) | 0.136 |
| Female, n (%) | 213 (30.4) | 65 (24.2) | 14 (28.0) | 0.158 |
| Marital Status, n (%) | 0.925 | |||
| married | 678 (96.7) | 261 (97.0) | 48 (96.0) | |
| single/widowed | 23 (3.3) | 8 (3.0) | 2 (4.0) | |
| Occupation, n (%) | 0.594 | |||
| technician/worker | 41 (5.8) | 16 (5.9) | 5 (10.0) | |
| civil Servants | 50 (7.1) | 21 (7.8) | 7 (14.0) | |
| farmer | 92 (13.1) | 29 (10.8) | 5 (10.0) | |
| retiree | 166 (23.7) | 60 (22.3) | 9 (18.0) | |
| others | 352 (50.2) | 143 (53.2) | 24 (48.0) | |
| BMI (kg/m2), mean ± SD | 22.70±3.14 | 22.42±3.01 | 22.44±2.68 | 0.413 |
| Health Insurance, n (%) | 0.052 | |||
| no | 343 (48.9) | 155 (57.6) | 25 (50.0) | |
| yes | 358 (51.1) | 114 (42.4) | 25 (50.0) | |
| Smoking Status, n (%) | 0.053 | |||
| non-smoker | 287 (73.0) | 89 (33.1) | 17 (34.0) | |
| former smoker | 216 (30.8) | 79 (29.4) | 15 (30.0) | |
| current smoker | 198 (28.2) | 101 (37.5) | 18 (36.0) | |
| Pack-years of cigarettes | 15 (0,40) | 24 (0,40) | 20 (0,40) | 0.013 |
| Alcohol Drinking, n (%) | 0.942 | |||
| never | 419 (49.8) | 157 (58.4) | 27 (54.0) | |
| sometimes | 148 (21.1) | 60 (22.3) | 12 (24.0) | |
| always | 134 (19.1) | 52 (19.3) | 11 (22.0) | |
| Number of chronic diseases@ | 1.64±1.53 | 1.56±1.46 | 1.50±1.27 | 0.627 |
| Patients with lung cancer surgery, n (%) | 242 (80.4) | 55 (18.3) | 4 (1.3) | <0.001 |
| Histology, n (%) | 0.052 | |||
| adenocarcinoma | 515 (73.5) | 171 (63.6) | 34 (68.0) | |
| squamous carcinoma | 97 (13.8) | 52 (19.3) | 8 (16.0) | |
| small cell carcinoma | 89 (12.7) | 46 (17.1) | 8 (16.0) | |
| Regimen of Chemotherapy, n (%) | 0.001 | |||
| single | 48 (6.8) | 32 (11.9) | 10 (20.0) | |
| combination | 653 (93.2) | 237 (88.1) | 40 (80.0) | |
| Metastasis, n (%) | 595 (85.0) | 245 (91.1) | 49 (98.0) | 0.003 |
| Clinical Stage, n (%) | <0.001 | |||
| I | 61 (8.7) | 9 (3.3) | 1 (2.0) | |
| II | 68 (9.7) | 15 (5.6) | 0 (0.0) | |
| III | 215 (30.7) | 77 (28.6) | 9 (18.0) | |
| IV | 357 (50.9) | 168 (62.5) | 40 (80.0) | |
| Radiotherapy, n (%) | 189 (27.0) | 103 (38.3) | 18 (36.0) | 0.002 |
Notes: Data are the Median (Q1, Q3) unless otherwise indicated. *Significance testing of the differences between groups were carried out using Kruskal-Wallis test, Pearson’s chi-square analysis or Fisher’s exact test or one-way analysis of variance as appropriate. @chronic diseases include hypertension, coronary heart disease, chronic obstructive pulmonary disease, asthma, digestive system diseases, diabetes mellitus, thyroid diseases, nervous system diseases, immunological diseases, renal diseases, urinary tract diseases, osteoarticular diseases and other chronic diseases (except lung cancer).
Abbreviations: BMI, body mass index; FI-LAB, frailty index based on laboratory variables.