TABLE 2.
KEGG pathways significantly overrepresented in up anddown-regulated genes in IVS of 2-week-old lambs from cortisol-treated (0.5 mg/kg/day) ewes compared to lambs of control ewes(n = 8 lambs per group; 4 males and 4 females).
| Up-regulated pathway names | #Genes | P-value | Genes |
| Protein processing in endoplasmic reticulum | 4 | 0.006 | SEC13, ERP29, SEC24C, HERPUD1 |
| Ubiquitin mediated proteolysis | 3 | 0.0195 | RCHY1, TCEB1, ANAPC11 |
| p53 signaling pathway | 2 | 0.0367 | RCHY1, TSC2 |
| Ribosome | 2 | 0.039 | UBA52, RPL13A |
| mRNA surveillance pathway | 2 | 0.039 | SYMPK, PABPC1 |
| Down-regulated pathway names | |||
| Spliceosome | 7 | 9.18E-06 | RBM17, PRPF3, SNRNP40, RBNP40, RBM25, PLRG1, SRSF1, PRPF40A, |
| Adipocytokine signaling pathway | 3 | 0.0173 | PRKAG2, CAMKK2, PRKAB2 |
| RNA degradation | 3 | 0.0173 | EXOSC2, CNOT10, EXOSC10 |
| Hypertrophic cardiomyopathy (HCM) | 3 | 0.0202 | PRKAG2, PRKAB2, TPM3, |
| RNA polymerase | 2 | 0.0223 | POLR3GL, POLR1B |
| Pathways in cancer | 5 | 0.0223 | LAMA4, RUNX1, RARA, TPM3, MITF |
| Base excision repair | 2 | 0.0223 | HMGB1, MBD4 |
| Lysosome | 3 | 0.0293 | LGMN, CD63, MANBA |
| Osteoclast differentiation | 3 | 0.0300 | CYLD, MAP3K7, MITF |
| RNA transport | 3 | 0.0404 | TGS1, NMD3, EEF1A1 |
| Acute myeloid leukemia | 2 | 0.0404 | RUNX1, RARA |
| Purine metabolism | 3 | 0.0423 | POLR3GL, POLR1B, PDE4B |