TABLE 3.
KEGG pathways significantly overrepresented in downregulated genes in EAT of 2-week-old lambs from cortisol-treated (0.5 mg/kg/day) (n = 9 lambs, 4 male and 5 female) compared to lambs of control ewes (n = 7, 3 male and 4 female).
| Down-regulated pathway names | #Genes | P-value | Genes |
| Metabolic pathways | 32 | 5.6E-05 | HSD17B1, COX5B, COX6C, COX6B1, GK, HK1, ACACB, UCK1, CMBL, NDUFAB1, PIGP, EPHX2, ADA, HMGCS1, HMGCS2, TMZSF2, DLD, HADHB, POLR1B, GMDS, DTYMK, FBP2, PANK1, ECHS1, DLST, CRLS1, ALDH5A1, ALDH1A1, PON3, ACLY, MLYCD, PAFAH1B2 |
| Peroxisome | 6 | 0.004 | MLYCD, PECR, SOD1, SOD2 PECR, PEX12, EPHX2 |
| Butanoate metabolism | 4 | 0.004 | HMGCS1, HMGCS2, ECHS1, ALDH5A1 |
| Huntington’s disease | 8 | 0.004 | TFAM, SOD1, SOD2, VDAC1, COX5B, COX6C, COX6B1, NDUFAB1 |
| Parkinson’s disease | 6 | 0.006 | COX5B, COX6C, COX6B1, VDAC1, NDUFAB1, UBE2G2 |
| Valine, leucine and isoleucine degradation | 5 | 0.006 | HMGCS1, HMHCS2, HADHB, DLD, ECHS1 |
| Citrate cycle (TCA cycle) | 3 | 0.030 | DLST, DLD, ACLY |
| Propanoate metabolism | 3 | 0.036 | MLYCD, ACACB, ECHS1 |
| Synthesis and degradation of ketone bodies | 2 | 0.036 | HMGCS1, HMHCS2 |
| Fatty acid elongation in mitochondria | 2 | 0.036 | ECHS1, HADHB |
| Terpenoid backbone biosynthesis | 2 | 0.046 | HMGCS1, HMHCS2 |
| Fructose and mannose metabolism | 3 | 0.046 | HK1, GMDS, FBP2 |