TABLE 2.

Dimorphic transition-associated genes found in ΔbrlA and ΔabaA transcriptomes

Gene category and namea	Tag locusb	Annotation	ΔbrlA/WT		ΔabaA/WT
			log2 R	Padjusted	log2 R	Padjusted
Central developmental pathway
brlA	BBA_07544	C2H2 transcription factor BrlA			−6.215	0.0000
abaA	BBA_00300	Conidiation factor AbaA	−1.991	0.0000
wetA	BBA_06126	Conidial maturation factor WetA	−0.730	0.0065	−0.794	0.0008
vosA	BBA_01023	Velvet protein VosA	−0.500	0.0815	−1.851	0.0000
Putative dimorphic switch genes
cdc42	BBA_01874	Cell division control protein 42	0.315	0.3189	−0.334	0.1225
drkA	BBA_01218	Group III histidine kinase HK3	0.568	0.0299	−0.244	0.2699
pakA	BBA_07438	PAK kinase	−0.247	0.4557	−0.442	0.0418
pakB	BBA_04136	Protein kinase CHM1	0.110	0.7880	−0.309	0.1519
racA	BBA_08808	Small GTPase, Rho type	0.342	0.2468	0.133	0.5968
ras1	BBA_04387	Ras GTPase 1 (Ras1)	−0.274	0.4143	−0.235	0.3013
ras2	BBA_04671	Ras GTPase 2 (Ras2)	−0.311	0.5188	−0.441	0.0713
ryp1	BBA_06411	Protein Ryp1	0.142	0.9702	−1.126	0.0004
ryp2	BBA_05501	Protein Ryp2	0.462	0.1065	0.226	0.3463
MAPK cascaded pathways
ste11	BBA_02280	MAPK kinase kinase Ste11	0.835	0.0011	0.821	0.0040
ste7	BBA_04254	MAPK kinase Ste7	−0.355	0.2180	−0.543	0.0077
fus3	BBA_01244	MAPK Fus3	−0.250	0.4698	−0.101	0.6658
ssk2	BBA_00937	MAPK kinase kinase Ssk2	0.027	0.9620	0.076	0.7790
pbs2	BBA_02330	MAPK kinase Pbns2	0.050	0.9158	−0.026	0.9326
hog1	BBA_05209	MAPK Hog1	0.814	0.0298	1.207	0.0240
bck1	BBA_01318	MAPK kinase kinase Bck1	−0.065	0.8808	−0.300	0.1701
mkk1	BBA_01095	MAPK kinase Mkk1	−0.109	0.7935	−0.135	0.5861
slt2	BBA_03334	MAPK Slt2	−1.079	0.0000	−0.481	0.0169

^aPutative dimorphic switch genes are homologous to those of human mycopathogens listed in a review (18).

^bGene accession codes in B. bassiana genome under the NCBI accession no. NZ_ADAH00000000.