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. 2018 Sep 24;21(4):781–789. doi: 10.1007/s11307-018-1262-3

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© The Author(s) 2018

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 4. — Voxel intensity histograms at a baseline (BL) and b 8 weeks (8W) with kernel fits of a metastasis in a patient with PD on [¹⁸F]fluoride PET/CT. As well as an increase in intensity of voxels (SUV_max rose from 32.7 to 38.0 and SUV_mean from 12.8–15.3), the histogram becomes less peaked (kurtosis decreased from 5.6 to 3.1).