Table 3.

Changes in parameter values for PD and non-PD after 8 weeks of treatment on [¹⁸F]FDG PET/CT with associated optimum and 25 % cut-off values and AUC

	PD (20 lesions/4 patients)							Non-PD (52 lesions/12 patients)					P value for PD vs non-PD
	Median change	Optimal cut-off (ROC curve analysis)		Number of lesions identified (↑ or ↓)		Number of patients identified (↑ or ↓)		Median change	Number of lesions identified (↑ or ↓)		Number of patients identified (↑ or ↓)
		Value	AUC	Opt cut-off	25 % cut-off	Opt cut-off	25 % cut-off		Opt cut-off	25 % cut-off	Opt cut-off	25 % cut-off
SUVmax (%)	− 2.2	− 20.6	0.76	18 ↑	2 ↑	4 ↑	0 ↑	− 27.2	33 ↓	52 ↓	7 ↓	12 ↓	0.001
SUVmean (%)	0.4	− 21.7	0.77	18 ↑	1 ↑	4 ↑	0 ↑	− 24.2	28 ↓	52 ↓	4 ↓	12 ↓	0.001
SUVpeak (%)	0.6	− 15.0	0.76	17 ↑	2 ↑	3 ↑	0 ↑	− 24.7	33 ↓	52 ↓	6 ↓	12 ↓	0.001
MTV (%)	10.7	− 14.1	0.70	17 ↑		4 ↑		− 19.7	30 ↓		6 ↓		0.006
TLM (%)	4.2	− 24.1	0.76	18 ↑		4 ↑		− 40.2	33 ↓		6 ↓		0.001
SD (%)	4.1	− 23.4	0.72	16 ↑		4 ↑		− 33.5	33 ↓		7 ↓		0.004
Ent (%)	− 0.7	− 2.2	0.55	15 ↑		4 ↑		− 1.1	33 ↑		7 ↑		0.458
Unif (%)	2.8	5.8	0.59	15 ↓		3 ↓		4.4	27 ↓		6 ↓		0.235
Kurt (abs)	0.1	0.2	0.51	16 ↓		4 ↓		0.09	29 ↓		7 ↓		0.826
Skew (abs)	0.05	− 0.13	0.55	14 ↑	0	4 ↑	0	− 0.03	29 ↑		6 ↑		0.517

MTV metabolic tumour volume, TLM tumour lesion metabolism, SD standard deviation, Ent entropy, Unif uniformity, Kurt kurtosis, Skew skewness, abs absolute change, % percentage change, ↑ ≥ the cut-off value, ↓ < the cut-off value