Table 1.

Participant characteristics at time of recruitment into CARE-E including age, epilepsy diagnosis, and concomitant anticonvulsant medications.

Participant ID	Age (years)	Weight (kg)	Epilepsy diagnosis	Predominant seizure types	Number of seizures in baseline month	Concomitant anticonvulsant therapies and daily dosage (mg/kg/day)
A-01	4–6	17.2	Dravet syndrome (SCN1A mutation)	Tonic-clonic, tonic, myoclonic	11	Stiripentol (50 mg/kg/day) Clobazam (1.3 mg/kg/day)
A-02	4–6	14.6	Dravet syndrome (SCN1A mutation)	Dialeptic, myoclonic (in clusters), Tonic-Clonic	343	Clobazam (0.3 mg/kg/day) Stiripentol (63 mg/kg/day) Topiramate (20 mg/kg/day)
A-03	4–6	23.7	Lennox Gastaut syndrome, continuous spike wave in sleep (evolved from cryptogenic infantile spasms)	Dialeptic, atonic, tonic	195	Valproic Acid (29 mg/kg/day) Clobazam (1.2 mg/kg/day) Lamotrigine (5.3 mg/kg/day) Levetiracetam (59 mg/kg/day)
A-04	1–3	11.4	Lennox Gastaut syndrome (Cerebral palsy-perinatal asphyxia)	Epileptic spasms, tonic, myoclonic	1,223	Lamotrigine (4 mg/kg/day) Valproic Acid (53 mg/kg/day)
A-05	1–3	14.3	Lennox Gastaut syndrome (cerebral palsy-perinatal asphyxia)	Atonic (in clusters), tonic, tonic-clonic	56	Lamotrigine (10.2 mg/kg/day) Clonazepam (0.08 mg/kg/day)
A-06	7–10	20.9	Dravet syndrome (SCN9A mutation)	Tonic clonic	10	Topiramate (9.6 mg/kg/day), Clonazepam (0.17 mg/kg/day) Valproic Acid (36 mg/kg/day)
A-07	4–6	18.6	Dravet syndrome (SCN1A mutation)	Atonic, tonic clonic, versive partial	165	Valproic Acid (19 mg/kg/day) Clobazam (1.1 mg/kg/day) Stiripentol (29 mg/kg/day)

Underlying aetiology of epileptic encephalopathy listed in parentheses.