Table 1.
Participant ID | Age (years) | Weight (kg) | Epilepsy diagnosis | Predominant seizure types | Number of seizures in baseline month | Concomitant anticonvulsant therapies and daily dosage (mg/kg/day) |
---|---|---|---|---|---|---|
A-01 | 4–6 | 17.2 | Dravet syndrome (SCN1A mutation) | Tonic-clonic, tonic, myoclonic | 11 | Stiripentol (50 mg/kg/day) Clobazam (1.3 mg/kg/day) |
A-02 | 4–6 | 14.6 | Dravet syndrome (SCN1A mutation) | Dialeptic, myoclonic (in clusters), Tonic-Clonic | 343 | Clobazam (0.3 mg/kg/day) Stiripentol (63 mg/kg/day) Topiramate (20 mg/kg/day) |
A-03 | 4–6 | 23.7 | Lennox Gastaut syndrome, continuous spike wave in sleep (evolved from cryptogenic infantile spasms) | Dialeptic, atonic, tonic | 195 | Valproic Acid (29 mg/kg/day) Clobazam (1.2 mg/kg/day) Lamotrigine (5.3 mg/kg/day) Levetiracetam (59 mg/kg/day) |
A-04 | 1–3 | 11.4 | Lennox Gastaut syndrome (Cerebral palsy-perinatal asphyxia) | Epileptic spasms, tonic, myoclonic | 1,223 | Lamotrigine (4 mg/kg/day) Valproic Acid (53 mg/kg/day) |
A-05 | 1–3 | 14.3 | Lennox Gastaut syndrome (cerebral palsy-perinatal asphyxia) | Atonic (in clusters), tonic, tonic-clonic | 56 | Lamotrigine (10.2 mg/kg/day) Clonazepam (0.08 mg/kg/day) |
A-06 | 7–10 | 20.9 | Dravet syndrome (SCN9A mutation) | Tonic clonic | 10 | Topiramate (9.6 mg/kg/day), Clonazepam (0.17 mg/kg/day) Valproic Acid (36 mg/kg/day) |
A-07 | 4–6 | 18.6 | Dravet syndrome (SCN1A mutation) | Atonic, tonic clonic, versive partial | 165 | Valproic Acid (19 mg/kg/day) Clobazam (1.1 mg/kg/day) Stiripentol (29 mg/kg/day) |
Underlying aetiology of epileptic encephalopathy listed in parentheses.