Table 2.
Univariate analysis of outcomes based on patient, disease, and transplant characteristics
| RI | NRM | LFS | OS | GRFS | aGVHD grade II-IV | aGVHD grade III-IV | cGVHD | Extensive cGVHD | |
|---|---|---|---|---|---|---|---|---|---|
| 2-y outcomes | |||||||||
| No ATG | 25.1 (21.1-29.3) | 16 (12.8-19.6) | 58.9 (54.2-63.5) | 63.7 (59.1-68.2) | 40.9 (36.2-45.6) | 33 (28.7-37.4) | 13 (10.1-16.2) | 46.2 (41.3-51) | 22.3 (18.5-26.4) |
| ATG | 26.1 (20.6-31.9) | 16.7 (12.2-21.7) | 57.2 (50.9-63.6) | 62.4 (56.1-68.6) | 43.3 (36.8-49.8) | 24.1 (18.8-29.7) | 7 (4.2-10.6) | 34.3 (28.1-40.6) | 16.4 (11.9-21.5) |
| 5-y outcomes | |||||||||
| No ATG | 29.1 (24.8-33.6) | 18.5 (14.9-22.4) | 52.4 (47.5-57.3) | 55.1 (50.1-60) | 33.2 (28.5-37.9) | 33 (28.7-37.4) | 13 (10.1-16.2) | 51.5 (46.4-56.3) | 27.3 (23-31.8) |
| ATG | 31.6 (25.4-38) | 18 (13.3-23.3) | 50.4 (43.6-57.2) | 54 (47.1-61) | 38.4 (31.8-45) | 24.1 (18.8-29.7) | 7 (4.2-10.6) | 36.8 (30.3-43.2) | 18.3 (13.4-23.8) |
| P | .78 | .98 | .74 | .74 | .28 | .01 | .01 | <.01 | .02 |
| Age | |||||||||
| Younger than median | 29.8 (24.7-35) | 16.5 (12.7-20.8) | 53.7 (48.1-59.4) | 56.5 (50.7-62.2) | 35.9 (30.4-41.4) | 33.7 (28.7-38.8) | 12.6 (9.3-16.3) | 45.5 (39.8-51.1) | 25.8 (21.1-30.8) |
| Older than median | 30.1 (25.1-35.2) | 20.1 (15.9-24.7) | 49.8 (44.2-55.4) | 52.9 (47.2-58.5) | 34 (28.6-39.4) | 26.3 (21.8-31.1) | 9.2 (6.5-12.5) | 47.4 (41.6-52.9) | 22.7 (18.1-27.6) |
| P | .60 | .27 | .18 | .14 | .41 | .04 | .10 | .71 | .41 |
| Disease status at allo-HCT | |||||||||
| CR1 | 28 (23.7-32.4) | 17.7 (14.3-21.5) | 54.3 (49.5-59.2) | 57.1 (52.2-62.1) | 37.1 (32.3-41.9) | 29.8 (25.7-33.9) | 10.8 (8.2-13.8) | 49.7 (44.7-54.4) | 25.1 (21-29.5) |
| CR2+ | 23.7 (16.8-31.3) | 21.1 (14.6-28.4) | 55.2 (46.6-63.7) | 59.4 (50.8-68) | 36.8 (28.4-45.2) | 24.6 (17.5-32.2) | 10 (5.7-15.6) | 41.3 (32.6-49.9) | 26.1 (18.8-34) |
| Advanced | 52.2 (39.6-63.3) | 16.7 (9.6-25.5) | 31.2 (20.1-42.3) | 32.9 (21.8-43.9) | 19.1 (9.3-28.9) | 39.8 (29.2-50.1) | 12.9 (6.8-21) | 36.1 (25-47.3) | 16.2 (9-25.2) |
| P | <.01 | .70 | <.01 | <.01 | <.01 | .04 | .64 | .07 | .52 |
| Cytogenetics | |||||||||
| Good | 18.9 (12.3-26.7) | 19 (12.4-26.7) | 62.1 (53-71.1) | 65.3 (56.2-74.3) | 40.4 (31.1-49.8) | 26.4 (18.8-34.7) | 11 (6.3-17.1) | 47.5 (37.8-56.6) | 29.8 (21.4-38.6) |
| Intermediate | 25.8 (21.3-30.6) | 17.8 (14-22) | 56.4 (51.1-61.7) | 60 (54.7-65.3) | 38 (32.7-43.2) | 32.2 (27.6-36.9) | 10.9 (8.1-14.3) | 51 (45.5-56.2) | 26.3 (21.6-31.2) |
| Poor | 46.1 (38.4-53.4) | 18.8 (13.3-25) | 35.1 (27.8-42.5) | 36.8 (29.1-44.5) | 24.5 (17.8-31.2) | 27.4 (21.1-34.1) | 10.7 (6.8-15.6) | 35.7 (28.3-43.1) | 16.5 (11.3-22.5) |
| P | <.01 | .99 | <.01 | <.01 | <.01 | .29 | 1.0 | .02 | .03 |
| KPS at allo-HCT | |||||||||
| <90% | 30.1 (22.4-38.2) | 26.7 (19.4-34.4) | 43.2 (34.6-51.8) | 43.5 (34.7-52.3) | 29.4 (21.4-37.5) | 31.9 (24.3-39.8) | 11.4 (6.8-17.4) | 45.7 (36.2-54.6) | 23.6 (16.6-31.4) |
| ≥90% | 30.1 (25.9-34.4) | 16.5 (13.3-20) | 53.4 (48.7-58) | 57.1 (52.4-61.7) | 36.5 (32-41) | 28.5 (24.6-32.4) | 10.2 (7.8-13) | 47.6 (42.9-52.1) | 24.7 (20.8-28.8) |
| P | .57 | .01 | .01 | <.01 | .02 | .38 | .77 | .40 | .92 |
| Donor type | |||||||||
| MSD | 31.8 (26.9-36.7) | 15.1 (11.6-19.1) | 53.1 (47.8-58.4) | 56.4 (51-61.8) | 34 (28.8-39.1) | 25.8 (21.6-30.2) | 9.6 (7-12.7) | 49.7 (44.2-54.9) | 27.5 (22.7-32.4) |
| UD 10/10 (HLA) | 28.9 (22.9-35.2) | 22.3 (17-28.2) | 48.8 (41.9-55.7) | 51.1 (44-58.3) | 36.7 (29.9-43.5) | 36.6 (30.2-42.9) | 11.5 (7.7-16) | 41.1 (34.2-47.8) | 19.9 (14.7-25.7) |
| UD 9/10 (HLA) | 23.8 (14.5-34.4) | 23.4 (14.3-33.9) | 52.8 (41-64.6) | 56.1 (44.6-67.6) | 33.3 (22.1-44.5) | 33.3 (22.5-44.6) | 16.2 (8.9-25.5) | 46.3 (33.7-58) | 21.7 (12.7-32.3) |
| P | .32 | .03 | .56 | .42 | .44 | .01 | .23 | .40 | .09 |
| Graft source | |||||||||
| BM | 19.4 (13.2-26.3) | 18.4 (12.5-25.2) | 62.3 (54.2-70.3) | 65.6 (57.5-73.7) | 44.5 (36.1-52.9) | 36.5 (28.5-44.5) | 10.6 (6.2-16.4) | 45.2 (36.5-53.5) | 21.5 (15-28.8) |
| PB | 33 (28.8-37.2) | 18.4 (15.1-22) | 48.6 (44.1-53.2) | 51.5 (46.9-56.1) | 32.2 (27.8-36.5) | 28.3 (24.6-32.2) | 11 (8.5-13.7) | 47.1 (42.4-51.5) | 25.1 (21.2-29.1) |
| P | .01 | .99 | .02 | .01 | .02 | .14 | .79 | .92 | .28 |
Other than P values, data are % (95% CI).