Table 3.
Patient | No. of IL-15 doses | CRS | Neurotoxicity | Ferritin, ng/mL | CRP, mg/L | IL-6 , pg/mL | Steroids | Tocilizumab | Disease response | ||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Onset (day) | Grade | Symptoms | Response | Onset (day) | Grade | Symptoms | Response | ||||||||
1 | 10 | 17 | 2 | Fever, rash | Yes | 44 | 3 | Confusion | Yes | 5 944 | 37 | 1 240 | Yes | Yes | CRi |
2 | 10 | 21 | 3 | Hypotension | Yes | — | — | — | — | 16 108 | 380 | 32 275 | Yes | Yes | PD |
3 | 8 | 11 | 2 | Hypoxia, rash | Yes | 11 | 2 | Confusion | Yes | 18 761 | 280 | 191 | No | No | CRi |
4 | 1 | 2 | 4 | Fever | No | 2 | 4 | Confusion, dysarthria, status epilepticus | Yes | 16 848 | 170 | 226 | Yes | No | PD |
5 | 9 | 8 | 1 | Fever, rash | Yes | — | — | — | — | — | — | — | No | No | PD |
6 | 6 | 7 | 1 | Fever, hypotension | Yes | — | — | — | — | 9 252 | 200 | 159 | Yes | No | PD |
7 | 7 | 8 | 4 | Fever, rash, hypotension | Yes | 22 | 4 | Confusion, dysarthria, status epilepticus | Yes | 133 439 | 150 | 125 | Yes | Yes | PD |
8 | 5 | 9 | 2 | Fever, hypotension | Yes | — | — | — | — | 50 408 | 160 | 248 | Yes | No | CRi |
9 | 10 | 7 | 4 | Hypoxia | No | 7 | 5 | Confusion, hemiparesis, intracranial hemorrhage | No | 13 711 | 420 | 243 | Yes | Yes | NE |