Table 4.
Trametinib pharmacokinetic parameters
| Cycle 1, day 1 | Cycle 2, day 1 | |||||
|---|---|---|---|---|---|---|
| tmax, h | Cmax, ng/mL | AUC6h, ng⋅h/mL | tmax, h | Cmax, ng/mL | AUC6h, ng⋅h/mL | |
| n | 10 | 10 | 10 | 6 | 6 | 3 |
| Mean | NC | 8.93 | 27.7 | NC | 28.0 | 120 |
| SD | NC | 3.34 | 10.1 | NC | 9.81 | 17.1 |
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