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. 2019 Jul 3;10:738. doi: 10.3389/fphar.2019.00738

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Copyright © 2019 Balducci and Forloni

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The multiple beneficial actions of Doxy in AD brains. In (A),an AD brain before treatment with Doxy. Different-sized Aβ plaques are widely deposited with activated microglial cells surrounding them. AβOs are freely circulating entities closer to or far from plaques, which, in concert with neuroinflammation, lead to memory impairment. (B) A Doxy-treated AD brain, where the beneficial effects of the drug are summarized. Plaque load can be reduced by long treatment. AβOs interact with Doxy, probably producing non-amyloidogenic and non-toxic structures; microglial cells move closer to a resting state. Both reduction in AβO load and microglial activation may be responsible for the Doxy-mediated memory recovery.

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