Table 4.

Cross-sectional analyses: coefficient estimates for group differences in global measures of integration, segregation, and distinctiveness between young and elderly

Measure	Coefficient	SE	t	p	Validation resultsa
Global efficiency	9.10e−4	4.38e−4	2.08	0.040*	2,3,4
Local efficiency	3.47e−3	1.06e−3	3.29	1.29e−3*	1,2,3,4
Mean participation coefficient	−0.010	1.21e−3	−8.31	1.32e−13*	1,2,3,4
System segregation	9.94e−3	1.28e−3	7.79	2.14e−12*	1,2,3,4

^aValidation results: 1, effect remains significant (p < 0.05) after controlling for mean relative motion and number of volumes; 2, effect remains significant (p < 0.05) after repeating the analyses in a subset of participants (young: n = 54; elderly: n = 68) with at least 150 volumes of good-quality imaging data (i.e., ≥5 min in length) remaining after scrubbing; 3, effect remains significant (p < 0.05) after maintaining equal scan lengths (123 volumes) across all participants; 4, effect remains significant (p < 0.05) after controlling for mean functional connectivity strength across all edges.

*Statistically significant effects (p < 0.05).