Table 5.

Longitudinal analyses: coefficient estimates for time, age, and age × time effects on global measures of integration, segregation, and distinctiveness in elderly

Measure	Predictor	Coefficient	SE	t	p	Validation resultsa
Global efficiency	Time*	−2.76e−4	1.21e−4	−2.28	0.023	2,4
	Age	3.57e−5	5.18e−5	0.69	0.490
	Age × time	1.32e−6	2.26e−5	0.06	0.954
Local efficiency	Time*	−7.73e−4	2.97e−4	−2.60	9.27e−3	1,2,4
	Age	−8.03e−5	1.26e−4	−0.64	0.524
	Age × time	1.76e−5	5.57e−5	0.32	0.752
Mean participation coefficient	Time*	9.55e−4	2.59e−4	3.69	2.24e−4	1,2,3,4
	Age*	3.61e−4	1.20e−4	2.99	2.76e−3	1,2,3,4
	Age × time	−1.76e−5	4.89e−5	−0.36	0.719
System segregation	Time*	−9.59e−4	2.68e−4	−3.58	3.40e−4	1,2,3,4
	Age*	−2.76e−4	1.16e−4	−2.37	0.018	1,3,4
	Age × time	3.63e−6	5.06e−5	0.07	0.943

^aValidation results: 1, effect remains significant (p < 0.05) after controlling for mean relative motion and number of volumes; 2, effect remains significant (p < 0.05) after repeating the analyses in a subset of participants (n = 68) with at least 150 volumes of good-quality imaging data (i.e., ≥5 min in length) remaining after scrubbing; 3, effect remains significant (p < 0.05) after maintaining equal scan lengths (123 volumes) across all participants; 4, effect remains significant (p < 0.05) after controlling for mean functional connectivity strength across all edges.

*Statistically significant effects (p < 0.05).