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. 2019 Jul 10;39(28):5534–5550. doi: 10.1523/JNEUROSCI.1451-18.2019

Table 7.

Cross-sectional analyses: coefficient estimates for group differences in proportion of node types between young and elderlya

Measure Coefficient SE t Uncorr p FDR-adj p Validation resultsb
Proportion of connector hubs
    Visual* −7.21 2.50 −2.88 4.67e−3 0.010 1,2,4
    SomMot/SalVentAttn A* −13.51 2.53 −5.34 4.26e−7 1.19e−5 1,2,3,4
    DorsAttn/Control A −2.00 2.07 −0.97 0.336 0.392
    SalVentAttn* −4.60 2.03 −2.27 0.025 0.039
    Default* −9.10 2.54 −3.59 4.74e−4 1.66e−3 1,2,3,4
    Control −3.15 2.17 −1.45 0.149 0.190
    Control C/Default C −0.25 2.57 −0.10 0.921 0.921
Proportion of satellite connectors
    Visual* −5.51 1.63 −3.37 9.87e−4 3.07e−3 1,2,4
    SomMot/SalVentAttn A* −7.61 1.99 −3.82 2.05e−4 8.20e−4 1,2,3,4
    DorsAttn/Control A* −4.78 1.69 −2.83 5.41e−3 0.011 2,3,4
    SalVentAttn −3.27 2.06 −1.59 0.114 0.152
    Default* −8.12 1.70 −4.77 4.96e−6 3.47e−5 1,2,3,4
    Control −1.55 2.26 −0.68 0.495 0.533
    Control C/Default C* −6.02 2.44 −2.47 0.015 0.024 2,3,4
Proportion of provincial hubs
    Visual* 8.17 2.66 3.07 2.64e−3 6.44e−3 1,2,3,4
    SomMot/SalVentAttn A* 12.88 2.56 5.03 1.68e−6 2.02e−5 1,2,3,4
    DorsAttn/Control A 2.65 1.95 1.36 0.178 0.217
    SalVentAttn* 5.04 1.52 3.32 1.17e−3 3.28e−3 1,2,3,4
    Default* 11.58 2.81 4.13 6.64e−5 3.72e−4 1,2,3,4
    Control* 3.23 1.48 2.18 0.031 0.046
    Control C/Default C 0.84 1.98 0.43 0.672 0.696
Proportion of peripheral nodes
    Visual* 4.55 1.63 2.80 5.97e−3 0.011 2,4
    SomMot/SalVentAttn A* 8.23 1.66 4.97 2.16e−6 2.02e−5 1,2,3,4
    DorsAttn/Control A* 4.14 1.35 3.05 2.76e−3 6.44e−3 2,3,4
    SalVentAttn 2.84 1.63 1.74 0.084 0.118
    Default* 5.65 1.47 3.83 2.00e−4 8.20e−4 1,2,3,4
    Control 1.46 1.59 0.92 0.360 0.403
    Control C/Default C* 5.44 2.10 2.59 0.011 0.019 2,4

aUncorr, Uncorrected; FDR-adj, false discovery rate-adjusted; DorsAttn, dorsal attention; SomMot, somatomotor; SalVentAttn, salience/ventral attention.

bValidation results: 1, effect remains significant (FDR-adjusted p < 0.05) after controlling for mean relative motion and number of volumes; 2, effect remains significant (FDR-adjusted p < 0.05) after repeating the analyses in a subset of participants (young: n = 54; elderly: n = 68) with at least 150 volumes of good-quality imaging data (i.e., ≥5 min in length) remaining after scrubbing; 3, effect remains significant (FDR-adjusted p < 0.05) after maintaining equal scan lengths (123 volumes) across all participants; 4, effect remains significant (FDR-adjusted p < 0.05) after controlling for mean functional connectivity strength across all edges.

*Statistically significant effects (FDR-adjusted p < 0.05).