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. 2019 Jul 10;39(28):5534–5550. doi: 10.1523/JNEUROSCI.1451-18.2019

Table 8.

Longitudinal analyses: coefficient estimates for time, age, and age × time effects on participation coefficient in elderlya

Measure Predictor Coefficient SE t Uncorr p FDR-adj p Validation resultsb
Visual Time 2.57e−4 6.09e−4 0.42 0.673 0.673
Age 2.00e−4 2.38e−4 0.84 0.401 0.458
Age × time −6.05e−5 1.14e−4 −0.53 0.597 0.686
DorsAttn Time 8.24e−4 4.09e−4 2.01 0.044 0.088
Age 1.56e−4 1.84e−4 0.85 0.396 0.458
Age × time −4.76e−5 7.63e−5 −0.62 0.532 0.686
SomMot/SalVentAttn A Time 6.11e−4 4.03e−4 1.52 0.129 0.207
Age 3.50e−4 1.71e−4 2.05 0.040 0.081
Age × time −4.34e−5 7.54e−5 −0.57 0.565 0.686
SalVentAttn Time* 1.50e−3 3.52e−4 4.27 1.97e−5 1.57e−4 1,2,4
Age* 5.16e−4 1.78e−4 2.90 3.73e−3 0.015 1,2,4
Age × time −4.67e−5 6.64e−5 −0.70 0.482 0.686
Limbic Time 3.50e−4 6.29e−4 0.56 0.579 0.661
Age 3.42e−4 3.20e−4 1.07 0.285 0.457
Age × time −8.75e−5 1.15e−4 −0.76 0.449 0.686
Control Time* 1.15e−3 3.35e−4 3.42 6.34e−4 1.69e−3 1,2,4
Age 3.87e−4 1.76e−4 2.19 0.028 0.075
Age × time 3.32e−5 6.33e−5 0.52 0.600 0.686
Control C/Default C Time 2.87e−4 4.30e−4 0.67 0.505 0.661
Age −2.98e−5 1.84e−4 −0.16 0.871 0.871
Age × time 7.73e−5 7.94e−5 0.97 0.330 0.686
Default Time* 1.59e−3 4.20e−4 3.79 1.52e−4 6.08e−4 1,2,3,4
Age* 6.47e−4 2.05e−4 3.16 1.59e−3 0.013 1,2,3,4
Age × time 1.72e−5 7.93e−5 0.22 0.829 0.829

aUncorr, Uncorrected; FDR-adj, false discovery rate-adjusted; DorsAttn, dorsal attention; SomMot, somatomotor; SalVentAttn, salience/ventral attention.

bValidation results: 1, effect remains significant (FDR-adjusted p < 0.05) after controlling for mean relative motion and number of volumes; 2, effect remains significant (FDR-adjusted p < 0.05) after repeating the analyses in a subset of participants (n = 68) with at least 150 volumes of good-quality imaging data (i.e., ≥5 min in length) remaining after scrubbing; 3, effect remains significant (FDR-adjusted p < 0.05) after maintaining equal scan lengths (123 volumes) across all participants; 4, effect remains significant (FDR-adjusted p < 0.05) after controlling for mean functional connectivity strength across all edges.

*Statistically significant effects (FDR-adjusted p < 0.05).