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. 2019 Jul 10;39(28):5581–5593. doi: 10.1523/JNEUROSCI.3025-18.2019

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Figure 8. — NKA inhibitors structurally distinct from digoxin induce disorganization of rod OSs. Photoreceptor OSs were labeled by anti-P/rds antibody (magenta), which binds to both cone and rod OSs, or by XAP-2 antibody, which specifically binds to rod OSs (magenta). A, Animals were treated with 1.0 μm ouabain for 3 or 7 d. B, Animals were treated with 3.5 μm wedelolactone for 3 or 7 d. C, Animals were treated with 3.0 μm istaroxime for 3 or 7 d. D, Animals were treated with 10.0 μm TTX for 3 or 7 d. Rod OSs were shorter and fewer after treatment with all the NKA inhibitors. Scale bars, 10 μm.