Fig. 5.

Changes in peripheral blood leukocyte counts following influenza challenge. a On days 1–7, 9, 11, and 13 following intranasal challenge with cell-grown HK/4801, blood samples were drawn and peripheral blood leukocytes were analyzed using flow cytometry as described in the Methods section. Mean percent of PBLs comprising CD4+ T cells (“CD4”), CD8+ T cells (“CD8”), or CD11b+ granulocytes (“granulocytes”) are shown as the mean of each group, with values normalized to values on the day of infection (day 0). Error bars represent one standard deviation; six ferrets per group until day 2 then three ferrets per group. b As above, with replicates combined. c Statistical significances of the differences between groups, as measured using a linear mixed model with repeated measures