Table 2.
Changes in lipid profiles according to free T4 quartiles.
| Lipid Profiles | Q1 (free T4 <1.13 ng/mL) |
Q2 (1.13–1.24 ng/mL) |
Q3 (1.25–1.34 ng/mL) |
Q4 (free T4 >1.35 ng/mL) |
p for Trend |
|---|---|---|---|---|---|
| Total cholesterol (mg/dL) | |||||
| Crude | Reference (1.0) | −1.6 ± 2.0 | −4.7 ± 2.1 | − 6.8 ± 1.9 | <0.001 |
| Model 1 | Reference (1.0) | −0.4 ± 2.0 | −2.2 ± 2.1 | −2.3 ± 1.9 | 0.143 |
| Model 2 | Reference (1.0) | −0.4 ± 2.0 | −1.5 ± 2.0 | −1.4 ± 1.9 | 0.374 |
| Model 3 | Reference (1.0) | −0.4 ± 2.0 | −1.6 ± 2.0 | −1.3 ± 1.8 | 0.378 |
| Model 4 | Reference (1.0) | −0.3 ± 2.0 | −1.2 ± 2.0 | −1.1 ± 1.9 | 0.488 |
| Model 5 | Reference (1.0) | 0.1 ± 2.0 | − 0.7± 2.1 | −0.5 ± 1.9 | 0.395 |
|
Triglyceride (mg/dL) |
|||||
| Crude | Reference (1.0) | 1.0 ± 7.5 | −6.2 ± 8.0 | −15.1 ± 1.3 | 0.056 |
| Model 1 | Reference (1.0) | −5.1 ± 7.1 | −12.5 ± 7.8 | −32.0 ± 7.8 | <0.001 |
| Model 2 | Reference (1.0) | −5.3 ± 7.0 | −9.6 ± 7.7 | −27.51 ± 7.7 | 0.001 |
| Model 3 | Reference (1.0) | −4.7 ± 6.9 | −9.8 ± 7.6 | −26.0 ± 7.6 | 0.001 |
| Model 4 | Reference (1.0) | −4.9 ± 6.9 | −11.3 ± 7.5 | −26.9 ± 7.7 | 0.001 |
| Model 5 | Reference (1.0) | −4.8 ± 7.1 | −11.1 ± 7.7 | −26.8 ± 8.0 | 0.001 |
| HDL-cholesterol (mg/dL) | |||||
| Crude | Reference (1.0) | −0.7 ± 0.7 | 0.44 ± 0.7 | 0.2 ± 0.6 | 0.412 |
| Model 1 | Reference (1.0) | −0.1 ± 0.6 | 1.0 ± 0.7 | 1.74 ± 0.6 | 0.002 |
| Model 2 | Reference (1.0) | −0.2 ± 0.6 | 0.6 ± 0.6 | 1.2 ± 0.6 | 0.036 |
| Model 3 | Reference (1.0) | −0.1 ± 0.6 | 0.6 ± 0.6 | 1.2 ± 0.6 | 0.026 |
| Model 4 | Reference (1.0) | −0.1 ± 0.6 | 0.7 ± 0.6 | 1.3 ± 0.6 | 0.014 |
| Model 5 | Reference (1.0) | 0.1 ± 7.6 | 0.7 ± 0.6 | 1.3 ± 0.6 | 0.014 |
| LDL-cholesterol (mg/dL) | |||||
| Crude | Reference (1.0) | −1.0 ± 1.9 | −3.9 ± 2.0 | −3.9 ± 1.2 | 0.013 |
| Model 1 | Reference (1.0) | 0.7 ± 1.9 | −0.6 ± 2.0 | 2.3 ± 1.9 | 0.337 |
| Model 2 | Reference (1.0) | 0.8 ± 1.9 | −0.1 ± 1.9 | 3.0 ± 1.8 | 0.167 |
| Model 3 | Reference (1.0) | 0.6 ± 1.8 | −0.3 ± 1.9 | 2.7 ± 1.8 | 0.213 |
| Model 4 | Reference (1.0) | 0.8 ± 1.8 | 0.4 ± 1.9 | 3.0 ± 1.8 | 0.129 |
| Model 5 | Reference (1.0) | 1.2 ± 1.8 | 0.8 ± 1.9 | 3.5 ± 1.9 | 0.080 |
| Non-HDL-cholesterol (mg/dL) | |||||
| Crude | Reference (1.0) | −0.8 ± 1.9 | −5.2 ± 2.1 | −6.9 ± 1.9 | <0.001 |
| Model 1 | Reference (1.0) | −03 ± 1.9 | −3.1 ± 2.1 | −4.1 ± 1.9 | 0.013 |
| Model 2 | Reference (1.0) | −0.2 ± 1.9 | −2.1 ± 2.0 | −2.5 ± 1.9 | 0.105 |
| Model 3 | Reference (1.0) | −0.3 ± 1.9 | −2.3 ± 2.0 | −2.6 ± 1.8 | 0.096 |
| Model 4 | Reference (1.0) | −0.2 ± 1.9 | −1.9 ± 2.0 | −2.4 ± 1.9 | 0.133 |
| Model 5 | Reference (1.0) | 0.2 ± 1.9 | −1.4 ± 2.0 | −1.8 ± 1.9 | 0.233 |
The association between free T4 quartiles and lipid profiles were performed by linear regression. Model 1: adjusted for age and sex; Model 2: Model 1 + body mass index; Model 3: Model 2 + smoking, alcohol consumption, and physical activity; Model 4: Model 3 + urine iodine, peroxidase antibody, and diabetes mellitus; Model 5: Model 4 + thyrotropin.