Table 3.
Risk of dyslipidemia according to free T4 quartiles.
| Presence of Dyslipidemia or Its Component | Q1 (Free T4 <1.13 ng/mL) |
Q2 (1.13–1.24 ng/mL) |
Q3 (1.25–1.34 ng/mL) |
Q4 (Free T4 >1.35 ng/mL) |
p for Trend |
|---|---|---|---|---|---|
| Dyslipidemia | |||||
| Crude | Reference (1.0) | 0.90(0.73–1.10) | 0.77 (0.61–0.97) | 0.65 (0.53–0.80) | <0.001 |
| Model 1 | Reference (1.0) | 0.92 (0.75–1.13) | 0.83 (0.66–1.06) | 0.74 (0.59–0.92) | 0.006 |
| Model 2 | Reference (1.0) | 0.92 (0.73–1.15) | 0.88 (0.68–1.14) | 0.80 (0.63–1.01) | 0.072 |
| Model 3 | Reference (1.0) | 0.92 (0.74–1.15) | 0.87 (0.68–1.13) | 0.81 (0.64–1.03) | 0.084 |
| Model 4 | Reference (1.0) | 0.92 (0.74–1.15) | 0.86 (0.67–1.11) | 0.80 (0.63–1.01) | 0.060 |
| Model 5 | Reference (1.0) | 0.92 (0.74–1.15) | 0.86 (0.67–1.12) | 0.81 (0.64.1.02) | 0.069 |
| Hypertriglyceridemia | |||||
| Crude | Reference (1.0) | 0.99 (0.78–1.26) | 0.97 (0.75–1.25) | 0.83 (0.65–1.06) | 0.125 |
| Model 1 | Reference (1.0) | 0.90 (0.70–1.17) | 0.89 (0.67–1.17) | 0.65 (0.50–0.86) | 0.002 |
| Model 2 | Reference (1.0) | 0.90 (0.68–1.18) | 0.95 (0.71–1.27) | 0.71 (0.53–0.95) | 0.031 |
| Model 3 | Reference (1.0) | 0.90 (0.68–1.19) | 0.95 (0.71–1.27) | 0.73 (0.54–0.97) | 0.047 |
| Model 4 | Reference (1.0) | 0.89 (0.67–1.17) | 0.92 (0.68–1.23) | 0.70 (0.52–0.95) | 0.027 |
| Model 5 | Reference (1.0) | 0.91 (0.68–1.20) | 0.94 (0.69–1.26) | 0.72 (0.53–0.98) | 0.044 |
| High LDL-cholesterol | |||||
| Crude | Reference (1.0) | 0.94 (0.75–1.18) | 0.74 (0.57–0.97) | 0.82 (0.64–1.04) | 0.040 |
| Model 1 | Reference (1.0) | 1.01 (0.80–1.29) | 0.87 (0.66–1.15) | 1.12 (0.87–1.44) | 0.665 |
| Model 2 | Reference (1.0) | 1.02 (0.80–1.30) | 0.90 (0.68–1.18) | 1.17 (0.90–1.51) | 0.427 |
| Model 3 | Reference (1.0) | 1.01 (0.79–1.28) | 0.88 (0.67–1.16) | 1.14 (0.88–1.48) | 0.525 |
| Model 4 | Reference (1.0) | 1.02 (0.80–1.30) | 0.91 (0.69–1.20) | 1.17 (0.90–1.51) | 0.386 |
| Model 5 | Reference (1.0) | 1.05 (0.82–1.34) | 0.94 (0.71–1.23) | 1.22 (0.93–1.58) | 0.255 |
| Non-HDL-cholesterol | |||||
| Crude | Reference (1.0) | 0.88 (0.70–1.12) | 0.76 (0.59–0.98) | 0.66 (0.52–0.85) | <0.001 |
| Model 1 | Reference (1.0) | 0.90 (0.70–1.15) | 0.82 (0.64–1.06) | 0.75 (0.58–0.97) | 0.019 |
| Model 2 | Reference (1.0) | 0.89 (0.69–1.15) | 0.86 (0.66–1.12) | 0.80 (0.61–1.04) | 0.087 |
| Model 3 | Reference (1.0) | 0.89 (0.69–1.15) | 0.85 (0.66–1.11) | 0.80 (0.61–1.05) | 0.086 |
| Model 4 | Reference (1.0) | 0.90 (0.70–1.17) | 0.88 (0.68–1.15) | 0.82 (0.63–1.07) | 0.135 |
| Model 5 | Reference (1.0) | 0.92 (0.70–1.19) | 0.89 (0.68–1.17) | 0.84 (0.64–1.10) | 0.184 |
The association between free T4 quartiles and dyslipidemia and component of dyslipidemia were performed by logistic regression analysis considering confounders. Dyslipidemia was defined as hypertriglycemia (TG ≥ 150 mg/dL), high LDL-cholesterol (LDL-cholesterol ≥ 130 mg/dL), and low HDL-cholesterol (HDL-cholesterol ≤ 40 mg/dL for males, ≤ 50 mg/dL for females). Model 1: adjusted for age and sex; Model 2: Model 1 + body mass index; Model 3: Model 2 + smoking, alcohol consumption, and physical activity; Model 4: Model 3 + urine iodine, peroxidase antibody, and diabetes mellitus; Model 5: Model 4 + thyrotropin.