Table 3.
Genes up and down-regulated in luxS during co-culture with B. fragilis relative to the WT C. difficile monoculture.
| No | Gene ID | log2FoldChange | Gene Annotation |
|---|---|---|---|
| 1 | CDR20291_0491 | 1.0964355 | RNA methylase |
| 2 | CDR20291_0492 | 1.1802034 | hypothetical protein |
| 3 | CDR20291_0493 | 1.0076105 | outer membrane lipoprotein |
| 4 | CDR20291_0715 | 1.6245725 | N-acetylmuramoyl-L-alanine amidase |
| 5 | CDR20291_1366 | 0.9274027 | ferrous ion transport protein |
| 6 | CDR20291_1374 | 1.1651176 | iron-sulfur protein |
| 7 | CDR20291_1691 | 1.4187304 | nitrite and sulfite reductase subunit |
| 8 | CDR20291_1716 | 1.3143654 | thiol peroxidase |
| 9 | CDR20291_1717 | 1.110872 | hypothetical protein |
| 10 | CDR20291_1934 | 1.5456229 | hypothetical protein |
| 11 | CDR20291_1936 | 1.3368874 | GntR family transcriptional regulator |
| 12 | CDR20291_1937 | 1.3736945 | ABC transporter ATP-binding protein |
| 13 | CDR20291_2389 | 1.2619709 | competence protein |
| 14 | CDR20291_2830 | 1.11333 | ribonucleoside-diphosphate reductase subunit alpha |
| 15 | CDR20291_2928 | 1.7538156 | PTS system transporter subunit IIABC |
| 16 | CDR20291_2930 | 1.5713168 | trehalose-6-phosphate hydrolase |
| 17 | CDR20291_3075 | 1.3649687 | osmoprotectant ABC transporter substrate-binding/permease |
| 18 | CDR20291_3104 | 0.8099098 | sigma-54-dependent transcriptional activator |
| 19 | CDR20291_3434 | 1.4402419 | homocysteine S-methyltransferase |
| 20 | CDR20291_0025 | −1.32053 | acetoin:2%2C6-dichlorophenolindophenol oxidoreductase subunit alpha |
| 21 | CDR20291_0615 | −0.86915 | nucleotide phosphodiesterase |
| 22 | CDR20291_0802 | −2.260047 | ABC transporter substrate-binding protein |
| 23 | CDR20291_0911 | −1.24181 | electron transfer flavoprotein subunit beta |
| 24 | CDR20291_1359 | −0.850952 | hypothetical protein |
| 25 | CDR20291_1370 | −1.124726 | tyrosyl-tRNA synthetase |
| 26 | CDR20291_1497 | −1.456296 | phosphomethylpyrimidine kinase |
| 27 | CDR20291_1498 | −1.727285 | hydroxyethylthiazole kinase |
| 28 | CDR20291_1499 | −1.276387 | thiamine-phosphate pyrophosphorylase |
| 29 | CDR20291_1591 | −1.51799 | dinitrogenase iron-molybdenum cofactor |
| 30 | CDR20291_1901 | −1.832663 | ABC transporter ATP-binding protein |
| 31 | CDR20291_1902 | −1.875507 | ABC transporter substrate-binding protein |
| 32 | CDR20291_1903 | −1.659329 | ABC transporter permease |
| 33 | CDR20291_1904 | −1.638609 | hypothetical protein |
| 34 | CDR20291_1925 | −1.54806 | flavodoxin |
| 35 | CDR20291_2474 | −1.434272 | DNA-directed RNA polymerase subunit omega |
| 36 | CDR20291_2515 | −1.603951 | amino acid permease family protein |
| 37 | CDR20291_2516 | −1.176482 | cobalt dependent x-pro dipeptidase |
| 38 | CDR20291_2660 | −0.958814 | teichuronic acid biosynthesis glycosyl transferase |
| 39 | CDR20291_2870 | −2.335518 | hypothetical protein |
| 40 | CDR20291_3142 | −1.665916 | pyrroline-5-carboxylate reductase |
| 41 | CDR20291_3143 | −1.830481 | formate acetyltransferase |
| 42 | CDR20291_3144 | −1.643573 | pyruvate formate-lyase 3 activating enzyme |
Note: P-adjusted value ≤ 0.05.