. 2019 May 23;5(2):42. doi: 10.3390/jof5020042

Table 2.

Cytokine responses by T cell phenotype among subjects with CM-IRIS vs. controls following GXM stimulation at CM diagnosis.

	Controls (n = 5)	CM-IRIS (n = 10)	p-Value
CD4⁺ T cells
Central memory (T_CM)
IFN-γ⁺	6 (3, 11)	0.8 (0, 3)	0.005
IL-2⁺	5 (2, 22)	1 (0.1, 3)	0.012
IL-17⁺	2 (1, 6)	0.5 (0, 2)	0.054
Effector memory (T_EM)
IFN-γ⁺	8 (4, 16)	0.5 (0, 3)	0.027
IL-2⁺	3 (2, 13)	0 (0, 0.1)	0.004
IL-17⁺	2 (1.9, 3)	0	<0.001
Terminally differentiated effector memory (T_TDEM)
IFN-γ⁺	3 (1, 16)	0 (0, 0.4)	0.005
IL-2⁺	74 (12, 86)	0	<0.001
IL-17⁺	0.1 (0, 1.1)	0 (0, 2)	0.624
CD8⁺ T cells
Central memory (T_CM)
IFN-γ⁺	2.4 (2.2, 3.1)	0.4 (0.1, 0.5)	<0.001
IL-2⁺	1.1 (0.5, 2.1)	0.07 (0.03, 0.3)	0.005
IL-17⁺	1.2 (0.9, 1.4)	0.08 (0.02, 0.2)	0.003
Effector memory (T_EM)
IFN-γ⁺	6.2 (3.1, 9.9)	0.7 (0.2, 1.5)	0.005
IL-2⁺	1.2 (0.5, 1.7)	0.01 (0, 0.1)	<0.001
IL-17⁺	1.2 (1.0, 1.3)	0.06 (0, 0.2)	<0.001
Terminally differentiated effector memory (T_TDEM)
IFN-γ⁺	1.3 (0.6, 3.5)	0.3 (0.2, 0.9)	0.037
IL-2⁺	1.1 (0.3, 1.2)	0.03 (0, 0.6)	0.068
IL-17⁺	0.09 (0.08, 0.25)	0.01 (0, 0.17)	0.119

Figures are presented as percentages of T cells. P-values obtained by Mann Whitney U test. Data are presented as median (Interquartile Range). Significant P values are in bold typeface.