Table 3.
Bivariate analysis of comorbidities and baseline characteristics for DAD and hospital mortality.
| Comorbidities | All Patients (n = 193) | Non DAD (n = 84) | DAD (n = 109) | p Value between DAD and Non-DAD | Survivors (n= 76) | Non Survivors (n = 117) | p Value between Survivors and Non Survivors |
|---|---|---|---|---|---|---|---|
| Active smoking † | 37 (19) | 17 (20) | 20 (18) | 0.884 | 18 (24) | 19 (16) | 0.273 |
| Active solid neoplasms † | 37 (19) | 12 (14) | 25 (23) | 0.184 | 13 (17) | 24 (21) | 0.689 |
| Active hemato-oncology neoplasm † | 32 (17) | 15 (18) | 17 (16) | 0.823 | 8 (11) | 24 (21) | 0.104 |
| Chemotherapy within the last 3 months † | 22 (11) | 9 (11) | 13 (12) | 0.973 | 9 (12) | 13 (11) | 1.000 |
| Organ transplant † | 7 (4) | 3 (4) | 4 (4) | 1.000 | 2 (3) | 5 (4) | 0.706 |
| Acute immunodeficiency syndrome/human immunodeficiency virus † | 7 (4) | 3 (4) | 4 (4) | 1.000 | 4 (5) | 3 (3) | 0.437 |
| Arterial hypertension † | 55 (28) | 25 (30) | 30 (28) | 0.857 | 20 (26) | 35 (30) | 0.705 |
| Coronary ischemia † | 22 (11) | 3 (4) | 19 (17) | 0.006 | 9 (12) | 13 (11) | 1.000 |
| Chronic cardiac failure (NYHA III or IV) † | 22 (11) | 8 (10) | 14 (13) | 0.623 | 11 (14) | 11 (9) | 0.394 |
| Chronic kidney injury † | 11 (6) | 5 (6) | 6 (6) | 1.000 | 3 (4) | 8 (7) | 0.532 |
| Diabetes mellitus † | 35 (18) | 17 (2) | 18 (17) | 0.633 | 16 (21) | 19 (16) | 0.511 |
| Diabetes mellitus requiring insulin † | 8 (4) | 4 (5) | 4 (4) | 0.730 | 7 (9) | 1 (1) | 0.007 |
| Domiciliary oxygen therapy † | 8 (4) | 6 (7) | 2 (2) | 0.080 | 3 (4) | 5 (4) | 1.000 |
| Inhaled β2 agonist † | 6 (3) | 2 (2) | 4 (4) | 0.699 | 4 (5) | 2 (2) | 0.214 |
| Inhaled steroids † | 11 (6) | 6 (7) | 5 (5) | 0.537 | 5 (7) | 6 (5) | 0.755 |
| Systemic steroids † | 26 (13) | 13 (15) | 13 (12) | 0.615 | 10 (13) | 16 (14) | 1.000 |
| Chronic obstructive pulmonary disease | 35 (18) | 12 (14) | 23 (21) | 0.303 | 16 (21) | 19 (16) | 0.511 |
| Baseline Characteristics | |||||||
| Female gender † | 66 (34) | 30 (36) | 36(33) | 0.813 | 27 (36) | 39 (33) | 0.874 |
| Age (years) ‡ | 61 (47) | 61 (46; 69) | 62 (47; 70) | 0.590 | 56 (45; 66) | 64 (49; 72) | 0.010 |
| Weight (kg) ‡ | 65 (57; 75) | 64 (54; 75) | 65 (58;75) | 0.321 | 65 (56; 85) | 65 (57; 74) | 0.813 |
| Hospital mortality | 117(61) | 43 (51) | 74 (68) | 0.027 | 35 (46) | 74 (63) | 0.227 |
| Days from ARDS to OLB ‡ | 6 (2; 12) | 7 (2; 13) | 6 (3; 11) | 0.324 | 6.5 (2; 11) | 6 (3, 12) | 0.540 |
| Days from hospital admission to ARDS ‡ | 3 (0; 9) | 3 (1; 8) | 3 (0; 11) | 0.897 | 2 (0; 9) | 3 (1; 9) | 0.700 |
| Length of hospital stay (days) ‡ | 39 (21; 62) | 39 (22; 57) | 40 (21; 63) | 0.652 | 47 (33; 82) | 34 (17; 53) | 0.000 |
| Length of ICU stay (days) ‡ | 29 (16; 47) | 29 (16; 44) | 29 (16; 47) | 0.751 | 33 (21; 57) | 26 (14; 38) | 0.001 |
| Days on invasive mechanical ventilation ‡ | 20 (11; 41) | 15 (11; 31) | 23 (11; 43) | 0.433 | 17 (11; 35) | 21 (11; 41) | 0.472 |
†n (%); ‡ median (first–third quartiles); ICU: intensive care unit; OLB: open lung biopsy; ARDS: acute respiratory distress syndrome; NYHA: New York Heart Association. Only dataset 1 is shown here; datasets 2–5 are reported in Tables S4 and S5.