Table 3.
Summary of automated hippocampal segmentation in left and right hemispheres in R-TN and control subjects (* p < .05, ** p < .01, *** p < .001).
| Subfield | Group | Mean volume right-side (mm3) | Mean volume left-side (mm3) | Difference (mm3) | Post-hoc P-value | Significance |
|---|---|---|---|---|---|---|
| Whole hippocampus | TN | 3308.57 | 3260.83 | 47.74 | 0.5120 | |
| CL | 3676.00 | 3529.70 | 146.30 | 0.0027 | ** | |
| GC-ML-DG | TN | 291.06 | 277.90 | 13.16 | 0.0153 | * |
| CL | 329.98 | 313.62 | 16.36 | 0.0053 | ** | |
| CA4 | TN | 252.04 | 240.07 | 11.97 | 0.0137 | * |
| CL | 281.29 | 268.42 | 12.87 | 0.0119 | * | |
| CA2/CA3 | TN | 212.94 | 193.78 | 19.16 | 0.0034 | ** |
| CL | 232.79 | 208.54 | 24.25 | 0.0007 | *** | |
| CA1 | TN | 607.34 | 591.73 | 15.61 | 0.6206 | |
| CL | 692.85 | 655.47 | 37.38 | 0.0047 | ** | |
| Subiculum | TN | 401.66 | 409.81 | −8.15 | 0.7095 | |
| CL | 440.86 | 439.00 | 1.86 | >0.9999 | ||
| Presubiculum | TN | 270.94 | 289.63 | −18.69 | 0.0017 | ** |
| CL | 297.07 | 306.41 | −9.34 | 0.4754 | ||
| Parasubiculum | TN | 58.66 | 63.02 | −4.36 | 0.0842 | |
| CL | 58.49 | 58.28 | 0.21 | >0.9999 | ||
| ML-HP | TN | 545.48 | 535.61 | 9.87 | 0.5087 | |
| CL | 609.67 | 587.12 | 22.55 | 0.0241 | * | |
| Fimbria | TN | 77.70 | 75.57 | 2.13 | >0.9999 | |
| CL | 89.93 | 85.95 | 3.98 | 0.9141 | ||
| Hippocampal tail | TN | 535.45 | 529.79 | 5.66 | >0.9999 | |
| CL | 579.08 | 547.57 | 31.51 | 0.0224 | * | |
| Hippocampal fissure | TN | 142.60 | 139.73 | 2.87 | >0.9999 | |
| CL | 144.24 | 134.68 | 9.56 | 0.1074 | ||
| HATA | TN | 55.31 | 53.93 | 1.38 | >0.9999 | |
| CL | 63.98 | 59.34 | 4.64 | 0.0045 | ** |
Subfield volume difference calculated as: VOIadj of ipsilateral (right) - VOIadj of contralateral (left).
Abbreviations: GC-ML-DG: granule cell and molecular layer of the dentate gyrus; CA: cornu ammonis; ML-HP: molecular layer of hippocampus proper; HATA: hippocampal amygdala transition area.