. Author manuscript; available in PMC: 2019 Aug 2.

Published in final edited form as: Basic Res Cardiol. 2018 Aug 2;113(5):33. doi: 10.1007/s00395-018-0691-0

Table 1.

Hemodynamic and coronary responses to graded changes in perfusion pressure

Coronary per-fusion pressure (mmHg)	140	130	120	110	100	90	80	70	60	50	40	CPP	Group	Interaction
Mean aortic pressure (mmHg)
Control	87 ± 7	87 ± 6	88 ± 6	88 ± 6	88 ± 6	87 ± 6	88 ± 6	88 ± 6	87 ± 6	87 ± 6	85 ± 6	P = 0.34	P < 0.001	P = 0.79
Hemodilution	86 ± 8	86 ± 8	81 ± 8	81 ± 7	80 ± 8	80 ± 8	80 ± 8	80 ± 8	84 ± 8	83 ± 8	82 ± 8
Hemodilution + dobutamine	91 ± 9	84 ± 8	74 ± 7	73 ± 6	66 ± 7^†	62 ± 6^†	60 ± 5^†	59 ± 4^†	59 ± 5^†	58 ± 5^†	58 ± 5^†
Heart rate (beats/min)
Control	74 ± 4	77 ± 3	75 ± 4	75 ± 4	77 ± 4	76 ± 4	77 ± 4	78 ± 4	78 ± 4	79 ± 4	80 ± 4	P = 0.72	P < 0.001	P = 0.99
Hemodilution	75 ± 6	75 ± 6	72 ± 6	71 ± 5	72 ± 5	73 ± 5	73 ± 4	73 ± 4	77 ± 3	77 ± 3	78 ± 3
Hemodilution + dobutamine	152 ± 8^†	151 ± 8^†	134 ± 11^†	134 ± 9^†	142 ± 7^†	140 ± 6^†	139 ± 5^†	140 ± 5^†	142 ± 5^†	143 ± 5^†	140 ± 4^†
Hematocrit (%)
Control	32 ± 2	32 ± 2	32 ± 2	32 ± 2	33 ± 2	33 ± 2	33 ± 2	33 ± 2	33 ± 2	34 ± 2	33 ± 2	P = 1.00	P < 0.001	P = 1.00
Hemodilution	17 ± 2^†	16 ± 2^†	16 ± 2^†	16 ± 2^†	16 ± 2^†	17 ± 2^†	17 ± 3^†	16 ± 2^†	16 ± 2^†	17 ± 2^†	16 ± 3^†
Hemodilution + dobutamine	18 ± 5^†	18 ± 6^†	21 ± 4^†	21 ± 4^†	21 ± 4^†	21 ± 4^†	20 ± 4^†	20 ± 4^†	19 ± 3^†	19 ± 4^†	19 ± 3^†
Coronary blood flow (mL/min/g)
Control	0.95 ± 0.09^*	0.83 ± 0.06^*	0.70 ± 0.05	0.67 ± 0.05	0.63 ± 0.04	0.58 ± 0.04	0.56 ± 0.04	0.50 ± 0.03	0.47 ± 0.03	0.38 ± 0.02^*	0.28 ± 0.03^*	P < 0.001	P < 0.001	P < 0.001
Hemodilution	1.62 ± 0.15^*^†	1.49 ± 0.12^†	1.43 ± 0.1^†	1.31 ± 0.07^†	1.25 ± 0.07^†	1.20 ± 0.06^†	1.08 ±s 0.08^†	1.02 ± 0.06^†	0.92 ± 0.05^*^†	0.79 ± 0.04^*^†	0.54 ± 0.05^*^†
Hemodilution + dobutamine	3.44 ± 0.42^†	3.18 ± 0.44^†	3.01 ± 0.26^†	2.86 ± 0.26^†	2.63 ± 0.22^†	2.30 ± 0.13^†	1.99 ± 0.11^*^†	1.76 ± 0.09^*^†	1.51 ± 0.09^*^†	1.23 ± 0.09^*^†	0.87 ± 0.06^*^†
MVO₂ (μL O₂/min/g)
Control	63 ± 2	61 ± 5	57 ± 6	62 ± 5	62 ± 6	62 ± 6	61 ± 5	58 ± 5	56 ± 4	49 ± 4	37 ± 5^*	P < 0.001	P < 0.001	P = 0.16
Hemodilution	70 ± 12	69 ± 9	59 ± 8	58 ± 8	56 ± 4	53 ± 3	54 ± 3	51 ± 2	44 ± 4	40 ± 4	30 ± 2
Hemodilution + dobutamine	175 ± 28^†	159 ± 36^†	128 ± 29^†	130 ± 30^†	130 ± 24^†	104 ± 26^†	101 ± 24^†	98 ± 22^†	81 ± 14	73 ± 11	60 ± 9
Coronary venous PO₂ (mmHg)
Control	28.7 ± 1.9	27.7 ± 3.0	25.0 ± 3.0	22.6 ± 2.5	20.1 ± 1.9	18.9 ± 2.4	17.6 ± 2.1	16.0 ± 2.0	15.4 ± 1.7	14.0 ± 1.9	13.4 ± 2.2	P < 0.001	P < 0.001	P = 0.97
Hemodilution	24.8 ± 3.4	25.0 ± 3.3	28.7 ± 5.3	26.8 ± 4.5	21.2 ± 2.9	24.8 ± 4.5	19.8 ± 2.7	19.2 ± 2.7	17.2 ± 2.1	16.2 ± 2.5	15.6 ± 2.3
Hemodilution + dobutamine	26.0 ± 2.3	26.0 ± 1.7	29.0 ± 2.6	28.2 ± 2.4	26.4 ± 2.8	26.3 ± 2.0	24.7 ± 2.3	22.5 ± 2.2	20.3 ± 2.3	18.8 ± 2.2	16.8 ± 1.4
Pzf (mmHg)
Control	30.3 ± 1.6^*		27.0 ± 1.0		25.0 ± 0.7		22.9 ± 0.5		20.6 ± 0.4^*		18.4 ± 0.5^*	P < 0.001	P < 0.001	P = 0.38s
Hemodilution	26.2 ± 1.9^*^†		24.2 ± 1.8		21.2 ± 1.8^†		18.8 ± 0.7^†		16.2 ± 0.7^*^†		15.2 ± 0.7^*^†
Hemodilution + dobutamine	16.0 ± 1.7^†		15.6 ± 1.5^†		14.8 ± 1.4^†		13.5 ± 1.1^†		11.7 ± 1.2^†		10.5 ± 1.2^†

P < 0.05 vs CPP 100 mmHg within the group

^†

P < 0.05 vs control at the same CPP