Fig. 3.

Proportion of trials classified consistently with FDA definitions. The proportion of master protocols consistent with the FDA definitions are shown in this figure. We compared all self-classified master protocols with the FDA definitions and their attributes (outlined in Table 1). In total, this review identified 89 self-classified master protocols (34 basket trials, 17 umbrella trials, 25 platform trials). 13 protocols self-identified as master protocols and therefore were included under ‘all master protocols’ only.