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. 2019 Jul 9;9:9952. doi: 10.1038/s41598-019-46346-x

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Ryuvidine repressed H3K4 demethylation in HEK293 cells expressing Flag-tagged KDM5A. Flag-tagged KDM5A was transiently overexpressed in HEK293 cells and cells were treated with ryuvidineat 2 uM for 48 h. Flag and H3K4me3 were detected by immunostaining; DAPI staining indicates nuclei. Transfection of empty vector did not produce Flag-positive cells and H3K4me3 was clearly detected. H3K4me3 was markedly reduced in Flag-positive cells in which KDM5A was overexpressed. Ryuvidine repressed the reduction of H3K4me3.