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. 2019 Jul 9;9:9952. doi: 10.1038/s41598-019-46346-x

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effect of ryuvidine on gefitinib-tolerant PC9 cells (DTEPs). (A) Ryuvidine inhibits growth of gefitinib-tolerant PC9 cells (DTEPs) but not parental PC9 cells. MTT values in the presence of DMSO alone were defined as 100%. Error bars show the means ± SD (n = 3). (B) Ryuvidine represses generation of DTEPs.