Table 1.

Potential KMD5A inhibitors identified by cell-based reporter assay.

Compound	IC50 (μM)a
Ryuvidine	1.4
Proflavine Hemisulfate	1.8
NSC95397	0.055
BVT948	2.6
Nitroxoline	5.0
Tolonium Chloride	1.7
Methylene Blue	1.1
Thimerosal	0.13
Pyrithione Zinc	0.32
Auranofin	1.6

^aIC₅₀ values were determined with AlphaScreen technology (see also Supplementary Fig. 2 where dose-dependent inhibition by ryuvidine is shown).

These compounds increased luciferase activity of the cell-based reporter assay by more than two-fold at 10 μM.