Table 5.

Semi-quantitative Gaucher disease bone marrow involvement scoring systems

Classification	Bone marrow burden (BMB)	Spanish MRI (S-MRI)	Terk	Rosenthal staging	Duseldorf bone marrow disease score	Vertebra-disc ratio
Sites	Femurs Lumbar spine	Femurs Lumbar spine Pelvis	Femurs	Lower extremities	Lower extremities	Lumbar spine
Considerations	Most validated method Correlates with quantitative Modified method allows use of STIR acquisition Confusion with red marrow in younger patients	Less validated Relevance of pelvis imaging is questioned Confusion with red marrow in younger patients	Does not appreciate more reversible changes seen within the axial skeleton Confusion with red marrow in younger patients	Less sensitive than methods including lumbar involvement Confusion with red marrow in younger patients	Correlates with severe disease Less sensitive than methods including lumbar spine	Quantitative region-of-interest based measurement Limited clinical validation data