Fig. 2.
Family-wise error rate and power-simulation studies. The trait is dichotomous, and region size is 200 kb. Several candidate window sizes were considered for WGScan, namely 5 kb, 10 kb, 15 kb, 20 kb, 25 kb and 50 kb. The left panel presents family-wise error rate comparison based on 105 replicates. M-Beta: method based on Beta distribution. M-Spectral-90%/95%/99%: method based on spectral decomposition, where leading eigenvalues account for 90%/95%/99% of the total variation (i.e., sum of all eigenvalues). The right panel presents power comparison based on 1000 replicates, with causal proportion 0.5%. WGScan: proposed test; sliding window: SKAT, Burden or SKAT-O test is applied to scan the region continuously using a sliding window of 10 kb, 20 kb or both, adjusted by Bonferroni correction for the total number of windows tested. Source data are provided as a Source Data file